Study of artificial cornea transplantation by using collagen cross-linking for corneal thinning disease

• Project/Area Number: 23791970
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: The University of Tokyo
• Principal Investigator: MIYAI Takashi 東京大学, 医学部附属病院, 助教 (40599007)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 角膜 / コラーゲン / 角膜クロスリンキング / 角膜菲薄化疾患 / コラーゲンクロスリンキング

Research Abstract

We studied changes of corneal property by UV-A collagen crosslinking, in order to develop artificial corneal stroma as a final goal. We attempted to establish a rating system using a rheometer, but reproducibility was insufficient. In a rabbit study of angiogenesis by suture neovascularization model, there was no difference between cross-linked eye and control. In a rabbit study to compare epithelium-on crosslinking with epithelium-off by anterior segment OCT, we found the level of demarcation line was shallow in epithelium-on eyes.

Research Products

• [Journal Article] Corneal thickness and volume measurements by swept source anterior segment optical coherence tomography in normal subjects (2013)
  • Author(s): Fukuda R, Usui T, Miyai T, Mori Y, Miyata K, Amano S
  • Journal Title: Curr Eye Res Volume: 38(5) Pages: 531-536
  • Peer Reviewed
• [Journal Article] Tear meniscus evaluation by anterior segment swept-source optical coherence tomography (2013)
  • Author(s): Fukuda R, Usui T, Miyai T, Yamagami S, Amano S
  • Journal Title: Am J Ophthalmol Volume: 155(4) Pages: 620-624
  • Peer Reviewed
• [Journal Article] Influences of cycloplegia with topical atropine on ocular higher-order aberrations (2013)
  • Author(s): Hiraoka T, Miyata K, Nakamura Y, Miyai T, Ogata M, Okamoto F, Oshika T
  • Journal Title: Ophthalmology Volume: 120(1) Pages: 8-13
  • Peer Reviewed
• [Journal Article] Relationship between total tear IgE and specific serum IgE in autumnal allergic conjunctivitis (2013)
  • Author(s): Mimura T, Usui T, Yamagami S, Miyai T, Amano S
  • Journal Title: Cornea Volume: 32(1) Pages: 14-19
  • Peer Reviewed
• [Journal Article] 円錐角膜の新しい治療 海外の現状 (2013)
  • Author(s): 宮井尊史
  • Journal Title: IOL ＆ RS Volume: 27 Pages: 44-47
• [Journal Article] Relation between total tear IgE and severity of acute seasonal allergic conjunctivitis (2012)
  • Author(s): Mimura T, Usui T, Yamagami S, Miyai T, Amano S
  • Journal Title: Curr Eye Res Volume: 37(10) Pages: 864-870
  • Peer Reviewed
• [Journal Article] Noninvasive observations of peripheral angle in eyes after penetrating keratoplasty using anterior segment fourier-domain optical coherence tomography (2012)
  • Author(s): Fukuda R, Usui T, Tomidokoro A, Mishima K, Matagi N, Miyai T, Amano S, Araie M
  • Journal Title: Cornea Volume: 31(3) Pages: 259-263
  • Peer Reviewed
• [Journal Article] Intraoperative mydriasis by intracameral injection of mydriatic eye drops: in vivo efficacy and in vitro safety studies (2011)
  • Author(s): Mori Y, Miyai T, Kagaya F, Nagai N, Osakabe Y, Miyata K, Amano S.
  • Journal Title: Clin Experiment Ophthalmol. Volume: 39(5) Pages: 456-461
  • Peer Reviewed
• [Journal Article] Limbal relaxing incisions using a reference point and corneal topography for intraoperative identification of the steepest meridian (2011)
  • Author(s): Miyata K, Miyai T, Minami K, Bissen-Miyajima H, Maeda N, Amano S
  • Journal Title: J Refract Surg Volume: 27(5) Pages: 339-44
  • Peer Reviewed
• [Presentation] インストラクションコース円錐角膜の最新の治療今後の展望 (2012)
  • Author(s): 宮井尊史
  • Organizer: 第27回日本白内障屈折矯正手術学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-06-16
• [Presentation] Frequencies and characteristics of renewing rigid gas permeable contact lenses in keratoconus patients (2012)
  • Author(s): Miyai T, Mimura T, Usui T, Yamagami S, Amano S.
  • Organizer: The Association for Research in Vision and Ophthalmology 2012 annual meeting
  • Place of Presentation: アメリカ、フォートローダーデール
  • Year and Date: 2012-05-09
• [Presentation] 円錐角膜の新しい治療 今後の展望
  • Author(s): 宮井尊史
  • Organizer: 第27回日本白内障屈折矯正手術学会学術総会
  • Place of Presentation: 東京
• [Presentation] Frequencies and characteristics of renewing rigid gas permeable contact lenses in keratoconus patients
  • Author(s): Takashi Miyai
  • Organizer: 2012 Annual Meeting of the Association for Research in Vision and Ophthalmology
  • Place of Presentation: Fort Lauderdale, FL, USA