Genetic susceptibility and cytokines levels in patients withage-related macular degeneration

• Project/Area Number: 23791972
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: University of Yamanashi
• Principal Investigator: SAKURADA Yoichi 山梨大学, 医学部附属病院, 助教 (90456476)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 加齢黄斑変性 / サイトカイン / 遺伝子多型 / 加齢黄斑変性症

Research Abstract

We investigated the association between aqueous humor cytokine levels and geneticsusceptibility in patients with age-related macular degeneration. Fourteen cytokineswere investigated including C-reactive protein (CRP) and vascular-endothelial growthfactor (VEGF).Aqueous CRP level was significantly higher in patients with age-relatedmacular degeneration than that in controls. We genotyped two major genetic loci inage-related macular degeneration.(i.e.rs10490924 in ARMS2 gene and rs800292 in CFH gene).There was no association of aqueous CRP level with ARMS and CFH variants. There werenot any differences in aqueous humor cytokines level between exudative typicalage-related macular degeneration and polypoidal choroidal vasculopathy.

Research Products

• [Journal Article] Systemic risk factors associated withpolypoidal choroidal vasculopathy andneovascular (2013)
  • Author(s): Sakurada Y, Yoneyama S, Imasawa M,Iijima H
  • Journal Title: age-related maculardegeneration Retina Volume: 33(4) Pages: 841-5
  • Peer Reviewed
• [Journal Article] Systemic risk factors associated with polypoidal choroidal vasculopathy and neovascular age related macular degeneration (2013)
  • Author(s): Yoichi Sakurada
  • Journal Title: Retina Volume: 33(4) Issue: 4 Pages: 841-5
  • DOI: 10.1097/iae.0b013e31826ffe9d
  • Peer Reviewed
• [Journal Article] Association of genetic variants on 8p21and 4q12 with age-related maculardegeneration in Asian populations (2012)
  • Author(s): Nakata I,Sakurada Y,Yoshimura N
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53(10) Pages: 6576-81
  • Peer Reviewed
• [Journal Article] Association between genetic variantsassociated with vertical cup-to-disc ratioand phenotypic features of primaryopen-angle glaucoma (2012)
  • Author(s): Mabuchi F, Sakurada Y,Kashiwagi K,Yamagata Z, Iijima H, Tsukahara S
  • Journal Title: Ophthalmology Volume: 119(9) Pages: 1819-25
  • Peer Reviewed
• [Journal Article] Recurrnece of macular edema associatedwith branch retinal vein occlusion afterintravitreal bevacizumab (2012)
  • Author(s): Hanada N, Iijima H, Sakuada Y, ImasawaM
  • Journal Title: Jpn Jophthalmol Volume: 56(2) Pages: 165-174
  • Peer Reviewed
• [Journal Article] Association of genetic variants on 8p21 and 4q12 with age-related macular degeneration in Asian populations (2012)
  • Author(s): Nakata Isao
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53(10 Pages: 6576-81
  • Peer Reviewed
• [Journal Article] Association between genetic variants associated with vertical cup-to-disc ratio and phenotypic features of primary open-angle glaucoma. (2012)
  • Author(s): Fumihiko Mabuchi
  • Journal Title: Ophthalmology Volume: 119(9) Issue: 9 Pages: 1819-25
  • DOI: 10.1016/j.ophtha.2012.02.044
  • Peer Reviewed
• [Journal Article] Recurrence of macular edema associated with branch retinal vein occlusion after intravitreal bevacizumab (2012)
  • Author(s): Hanada, N.
  • Journal Title: Japanese journal of ophthalmology Volume: 56 Issue: 2 Pages: 165-174
  • DOI: 10.1007/s10384-011-0113-4
  • Peer Reviewed
• [Journal Article] Role of complement factor H I62V and age-related maculopathy susceptibility 2 A69S varinats in the clinical expression of polypoidal choroidal vasculopathy (2011)
  • Author(s): Sakurada Y,Kubota T,Imasawa M,Mabuchi F,Tateno Y,Tnabe N,Iijima H
  • Journal Title: Ophthalmology Volume: 118(7) Pages: 1402-1407
  • Peer Reviewed
• [Journal Article] Polymorphisms in ARMS2 (LOC387715) and LOXL1 genes in the Japanese with age-related macular degeneration (2011)
  • Author(s): Sakurada Y, Mabuchi F, Yoneyama S, Kubota T, Iijima H.
  • Journal Title: American journal of ophtahlmology Volume: 152(3) Pages: 499-499
  • Peer Reviewed
• [Journal Article] Association between SRBD1 and ELOVL5 gene polymorphisms and primary open-angle glaucoma. (2011)
  • Author(s): Mabuchi F, Sakurada Y, Kashiwagi K, Yamagata Z, Iijima H, Tsukahara S.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52(7) Pages: 4626-4629
  • Peer Reviewed
• [Journal Article] Classic choroidal neovascularization developing after photodynamic therapy in eyes with polypoidal choroidal vasculopathy (2011)
  • Author(s): Imasawa M, Sakurada Y, Iijima H.
  • Journal Title: Jpn J Ophthalmol. 2011 May;55(3):241-7. Volume: 55(3) Pages: 241-7
  • NAID: 10029021297
  • Peer Reviewed
• [Journal Article] A remote operating slit lamp microscope system. Development and its utility in ophthalmologic examinations. (2011)
  • Author(s): Tanabe N, Go K, Sakurada Y, Imasawa M, Mabuchi F, Chiba T, Abe K, Kashiwagi K
  • Journal Title: Methods Inf Med Volume: 50(5) Pages: 427-34
  • Peer Reviewed
• [Presentation] ポリープ状脈絡膜血管症の表現型とARMS2遺伝子多型 (2013)
  • Author(s): 櫻田庸一
  • Organizer: 日本眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-06
• [Presentation] 加齢黄斑変性に対するルセンティス硝子体注射1年後の視力関連因子 (2013)
  • Author(s): 米山征吾
  • Organizer: 日本眼科学会
  • Year and Date: 2013-04-04
• [Presentation] ポリープ状脈絡膜血管症の表現型とARMS2遺伝子多型 (2013)
  • Author(s): 櫻田庸一
  • Organizer: 日本眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都）
  • Invited
• [Presentation] 加齢黄斑変性に対するルセンティス硝子体注射治療1年後の視力関連因子 (2013)
  • Author(s): 米山征吾
  • Organizer: 日本眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都）
• [Presentation] ポリープ状脈絡膜血管症の中心窩脈絡膜厚 (2012)
  • Author(s): 米山征吾
  • Organizer: 日本網膜硝子体学会
  • Year and Date: 2012-12-01
• [Presentation] 加齢黄斑変性に必要なゲノム学を理解しよう
  • Author(s): 櫻田庸一
  • Organizer: 日本臨床眼科学会
  • Place of Presentation: 東京
• [Presentation] ポリープ状脈絡膜血管症に対するラニビズマブ併用光線力学的療法の視力予後関連因子
  • Author(s): 櫻田庸一，渡辺勝，飯島裕幸
  • Organizer: 網膜硝子体，眼循環学会
  • Place of Presentation: 東京
• [Book] 眼科 (2011)
  • Author(s): 櫻田庸一
  • Total Pages: 6
  • Publisher: 金原出版
• [Remarks]
• [Remarks]
  • URL: http://www.med.yamanashi.ac.jp/clinical/ophthal/