Elucidation of role of adiponectin in regulation of ischemic retinopathy

• Project/Area Number: 23791976
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Nagoya University
• Principal Investigator: HIGUCHI Akiko 名古屋大学, 医学部附属病院, 助教 (50599032)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 虚血性網膜症 / 血管新生 / 炎症 / アディポサイトカイン

Research Abstract

Ischemic retinopathy such as diabetic retinopathy is one of serious blinding diseases. Adiponectin is an adipose-derived secreted protein that has beneficial effects on type 2 diabetes and its macrovascular complications. Our study with gain of function and loss of function genetic manipulations demonstrated that adiponectinprotects against the development of ischemic retinal injury in a mouse model of oxygen-induced retinopathy through its ability to attenuate inflammatory response and pathological neovascularization in the retina. Thus, adiponectin may represent a molecular target for the prevention and treatment of ischemic retinopathy.

Research Products

• [Journal Article] Omentin as a novel biomarker of metabolic risk factors (2012)
  • Author(s): Shibata R, Ouchi N, Takahashi R, Terakura Y, Ohashi K, Ikeda N, Higuchi A, Terasaki H, Kihara S, Murohara T
  • Journal Title: Diabetol Metab Syndr Volume: 4 Issue: 1 Pages: 37-37
  • DOI: 10.1186/1758-5996-4-37
  • Peer Reviewed
• [Journal Article] The polyphenols resveratrol and s17834 prevent the structural and functional sequelae of diet-induced metabolic heart disease in mice. (2012)
  • Author(s): Qin F, Siwik DA, Luptak I, Hou X, Wang L, Higuchi A, Weisbrod RM, Ouchi N, Tu VH, Calamaras TD, Miller EJ, Verbeuren TJ, Walsh K, Cohen RA, Colucci WS.
  • Journal Title: Circulation. Volume: 125(14) Issue: 14 Pages: 1757-64
  • DOI: 10.1161/circulationaha.111.067801
  • Peer Reviewed
• [Journal Article] Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver. (2012)
  • Author(s): Wanninger J
  • Journal Title: Mol Cell Endocrinol. Volume: 26 Issue: 2 Pages: 248-54
  • DOI: 10.1016/j.mce.2011.10.032
  • Peer Reviewed
• [Journal Article] Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver. (2012)
  • Author(s): Wanninger J, Bauer S, Eisinger K, Weiss TS, Walter R, Hellerbrand C, Schäffler A, Higuchi A, Walsh K, Buechler C.
  • Journal Title: Mol Cell Endocrinol. Volume: 349 Pages: 248-54
  • Peer Reviewed
• [Journal Article] Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload. (2011)
  • Author(s): Shimano M, Ouchi N, Nakamura K, van Wijk B, Ohashi K, Asaumi Y, Higuchi A, Pimentel DR, Sam F, Murohara T, van den Hoff MJ, Walsh K.
  • Journal Title: Proc Natl A c a d S c i U S A . Volume: 25;108 Issue: 43
  • DOI: 10.1073/pnas.1108559108
  • Peer Reviewed
• [Journal Article] Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism (2011)
  • Author(s): Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N
  • Journal Title: J Biol Chem Volume: 286 Issue: 40 Pages: 34552-8
  • DOI: 10.1074/jbc.m111.277319
  • Peer Reviewed
• [Journal Article] Cardiac myocyte-specific ablation of follistatin-like 3 attenuates stress-induced myocardial hypertrophy (2011)
  • Author(s): Shimano M, Ouchi N, Nakamura K, Oshima Y, Higuchi A, Pimentel DR, Panse KD, Lara-Pezzi E, Lee SJ, Sam F, Walsh K
  • Journal Title: J Biol Chem Volume: 286 Issue: 11 Pages: 9840-8
  • DOI: 10.1074/jbc.m110.197079
  • Peer Reviewed
• [Journal Article] Cardiac myocyte-specific ablation of follistatin-like 3 attenuates stress-induced myocardial hypertrophy. (2011)
  • Author(s): Shimano M, Ouchi N, Nakamura K, Oshima Y, Higuchi A, Pimentel DR, Panse KD, Lara-Pezzi E, Lee SJ, Sam F, Walsh K.
  • Journal Title: J Biol Chem. Volume: 286 Pages: 9840-8
  • Peer Reviewed
• [Journal Article] Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload. (2011)
  • Author(s): Shimano M, Ouchi N, Nakamura K, van Wijk B, Ohashi K, Asaumi Y, Higuchi A, Pimentel DR, Sam F, Murohara T, van den Hoff MJ, Walsh K.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 108
  • Peer Reviewed