Developing a method for diagnosis of cancer associated retinopathy and investigation of its pathology

• Project/Area Number: 23791977
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Nagoya University
• Principal Investigator: UENO Shinji 名古屋大学, 医学系研究科, 助教 (80528670)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 腫瘍関連網膜症 / 網膜電図 / 細胞死 / 自己抗体 / 双極細胞 / 腫瘍随伴網膜症 / TRPM1

Research Abstract

In this study I evaluated serum ofthe paraneoplastic retinopathy patients who had retinal ON bipolar dysfunction. I found two patients who had anti-TRPM1 antibodies. I injected sera from one of the patients to mice intravitreously. I discovered the sera caused acute retinal ON bipolar cell death. From our results we suggested retinal dysfunction of the patients were caused by retinal ON bipolar degeneration. We also found intravitreous injection of the serum of paraneoplastic retinopathy patients to mouse eye had a potential to elucidate the mechanisms the diseases. This ON bipolar specific degeneration is a novel finding.

Research Products

• [Journal Article] Focal macular electroretinograms after intravitreal injections of bevacizumab for age-related macular degeneration. (2012)
  • Author(s): Iwata E, Ueno S, Ishikawa K, Ito Y, Uetani R, Piao CH, Kondo M, Terasaki H.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 28;53(7) Pages: 4185-4190
  • Peer Reviewed
• [Journal Article] Presynaptic dystroglycan-pikachurin complex regulates the proper synaptic connection between retinal photoreceptor and bipolar cells (2012)
  • Author(s): Omori Y, Araki F, Chaya T, Kajimura N, Irie S, Terada K, Muranishi Y, Tsujii T, Ueno S, Koyasu T, Tamaki Y, Kondo M, Amano S, Furukawa T.
  • Journal Title: J Neurosci. Volume: 2;32(18) Pages: 6126-6137
  • Peer Reviewed
• [Journal Article] Photoreceptor and post-photoreceptoral contributions to photopic ERG a-wave in rhodopsin P347L transgenic rabbits (2012)
  • Author(s): Hirota R, Kondo M, Ueno S, Sakai T, Koyasu T, Terasaki H.
  • Journal Title: Invest Ophthalmol Vis Sci. Volume: 15;53(3) Pages: 1467-1472
  • Peer Reviewed
• [Journal Article] Two novel mutations in the EYS gene are possible major causes of autosomal recessive retinitis pigmentosa in the Japanese population. (2012)
  • Author(s): Hosono K, Ishigami C, Takahashi M, Park DH, Hirami Y, Nakanishi H, Ueno S, Yokoi T, Hikoya A, Fujita T, Zhao Y, Nishina S, Shin JP, Kim IT, Yamamoto S, Azuma N, Terasaki H, Sato M, Kondo M, Minoshima S, Hotta Y.
  • Journal Title: PLoS One. Volume: 7(2)
  • Peer Reviewed
• [Journal Article] miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression (2011)
  • Author(s): Sanuki R, Onishi A, Koike C, Muramatsu R, Watanabe S, Muranishi Y, Irie S, Ueno S, Koyasu T, Matsui R, Cherasse Y, Urade Y, Watanabe D, Kondo M, Yamashita T, Furukawa T
  • Journal Title: Nat Neurosci Volume: 21;14(9) Pages: 1125-1134
  • Peer Reviewed
• [Journal Article] Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction (2011)
  • Author(s): Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T.
  • Journal Title: PLoS One. Volume: 6(5)
  • Peer Reviewed
• [Presentation] 腫瘍関連網膜症におけるON型双極細胞の機能障害機序. (シンポジウム) (2012)
  • Author(s): 上野 真治
  • Organizer: 第60回日本臨床視覚電気整理学会
  • Place of Presentation: ミッドランドホール・名古屋市
  • Year and Date: 2012-10-06
• [Presentation] 腫瘍随伴網膜症における抗TRPM1自己抗体の双極細胞機能障害の作用機序 (2012)
  • Author(s): 上野 真治
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム・東京都
  • Year and Date: 2012-04-05
• [Presentation] AIRはあるか (シンポジウム) (2011)
  • Author(s): 上野 真治
  • Organizer: 第45回眼炎症学会
  • Place of Presentation: 京都国際会議場・京都市
  • Year and Date: 2011-07-09
• [Presentation] こんな時こそERG VEPを (シンポジウム) (2011)
  • Author(s): 上野 真治
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム・東京都
  • Year and Date: 2011-05-14
• [Presentation] 腫瘍随伴網膜症におけるon型双極細胞に対する自己抗体とその作用機序 (2011)
  • Author(s): 上野 真治
  • Organizer: 第45回日本眼炎症学会(招待講演)
  • Place of Presentation: 国立京都国際会館
• [Presentation] 腫瘍随伴網膜症における抗TRPM1自己抗体の双極細胞障害の機序
  • Author(s): 上野 真治
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京国際フォーラム
• [Presentation] 腫瘍随伴網膜症におけるON型双極細胞障害の機序
  • Author(s): 上野 真治
  • Organizer: 第60回日本臨床視覚電気生理学会
  • Place of Presentation: 名古屋ミッドランドホール