Developing a method for diagnosis of cancer associated retinopathy and investigation of its pathology
| Project/Area Number |
23791977
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Nagoya University |
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Principal Investigator |
UENO Shinji 名古屋大学, 医学系研究科, 助教 (80528670)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 腫瘍関連網膜症 / 網膜電図 / 細胞死 / 自己抗体 / 双極細胞 / 腫瘍随伴網膜症 / TRPM1 |
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| Research Abstract |
In this study I evaluated serum ofthe paraneoplastic retinopathy patients who had retinal ON bipolar dysfunction. I found two patients who had anti-TRPM1 antibodies. I injected sera from one of the patients to mice intravitreously. I discovered the sera caused acute retinal ON bipolar cell death. From our results we suggested retinal dysfunction of the patients were caused by retinal ON bipolar degeneration. We also found intravitreous injection of the serum of paraneoplastic retinopathy patients to mouse eye had a potential to elucidate the mechanisms the diseases. This ON bipolar specific degeneration is a novel finding.
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Report
(3 results)
Research Products
(13 results)
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[Journal Article] Presynaptic dystroglycan-pikachurin complex regulates the proper synaptic connection between retinal photoreceptor and bipolar cells2012
Author(s)
Omori Y, Araki F, Chaya T, Kajimura N, Irie S, Terada K, Muranishi Y, Tsujii T, Ueno S, Koyasu T, Tamaki Y, Kondo M, Amano S, Furukawa T.
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Journal Title
J Neurosci.
Volume: 2;32(18)
Pages: 6126-6137
Related Report
Peer Reviewed
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[Journal Article] Two novel mutations in the EYS gene are possible major causes of autosomal recessive retinitis pigmentosa in the Japanese population.2012
Author(s)
Hosono K, Ishigami C, Takahashi M, Park DH, Hirami Y, Nakanishi H, Ueno S, Yokoi T, Hikoya A, Fujita T, Zhao Y, Nishina S, Shin JP, Kim IT, Yamamoto S, Azuma N, Terasaki H, Sato M, Kondo M, Minoshima S, Hotta Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] miR-124a is required for hippocampal axogenesis and retinal cone survival through Lhx2 suppression2011
Author(s)
Sanuki R, Onishi A, Koike C, Muramatsu R, Watanabe S, Muranishi Y, Irie S, Ueno S, Koyasu T, Matsui R, Cherasse Y, Urade Y, Watanabe D, Kondo M, Yamashita T, Furukawa T
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Journal Title
Nat Neurosci
Volume: 21;14(9)
Pages: 1125-1134
Related Report
Peer Reviewed
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[Journal Article] Identification of autoantibodies against TRPM1 in patients with paraneoplastic retinopathy associated with ON bipolar cell dysfunction2011
Author(s)
Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Adamus G, Furukawa T.
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Journal Title
Related Report
Peer Reviewed
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