Analysis of pathology and development of treatment for dry age-related macular degeneration using adaptive optics scanning laser ophthalmoscopy

• Project/Area Number: 23791979
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Kyoto University
• Principal Investigator: OOTO Sotaro 京都大学, 医学研究科, 助教 (10511850)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 加齢黄斑変性 / 眼底イメージング / 視細胞 / 補償光学

Research Abstract

We investigated the pathology and the mechanism of progressionof dry age-related macular degeneration at the cellular level using adaptive optics scanning laser ophthalmoscopy . Cone density was decreased and cone arrangement was irregular, and cone density correlated with visual function in dry age-related macular degeneration. This study proposed the evaluation of the treatment for this disease.

Research Products

• [Journal Article] Photoreceptor damage and foveal sensitivity in surgically closed macular holes: an adaptive optics scanning laser ophthalmoscopy study. (2012)
  • Author(s): Ooto S
  • Journal Title: Am J Ophthalmol Volume: 154 Issue: 1 Pages: 174-186
  • DOI: 10.1016/j.ajo.2012.01.031
  • NAID: 120004398100
  • Peer Reviewed
• [Journal Article] High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy (2012)
  • Author(s): Takayama K, Ooto S, Hangai M, Arakawa N, Oshima S, Shibata N, Hanebuchi M, Inoue T, Yoshimura N
  • Journal Title: PLoS One Volume: 7(3) Issue: 3 Pages: e33158-e33158
  • DOI: 10.1371/journal.pone.0033158
  • NAID: 120003988392
  • Peer Reviewed
• [Journal Article] Assessment of macular choroidal thickness by optical coherence tomography and angiographic changes in central serous chorioretinopathy. (2012)
  • Author(s): Jirarattanasopa P
  • Journal Title: Ophthalmology Volume: 119 Issue: 8 Pages: 1666-1678
  • DOI: 10.1016/j.ophtha.2012.02.021
  • Peer Reviewed
• [Journal Article] Choroidal thickness, vascular hyperpermeability, and complement factor h in age-related macular degeneration and polypoidal choroidal vasculopathy. (2012)
  • Author(s): Jirarattanasopa P
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Issue: 7 Pages: 3663-3672
  • DOI: 10.1167/iovs.12-9619
  • Peer Reviewed
• [Journal Article] High-resolution photoreceptor imaging in idiopathic macular telangiectasia type 2 using adaptive optics scanning laser ophthalmoscopy. (2011)
  • Author(s): Ooto S, Hangai M, Takayama K, Arakawa N, Tsujikawa A, Koizumi H, Oshima S, Yoshimura N.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Pages: 5541-5550
  • Peer Reviewed
• [Journal Article] Photoreceptor restoration in unilateral acute idiopathic maculopathy on adaptive optics scanning laser ophthalmoscopy. (2011)
  • Author(s): Ooto S, Hangai M, Yoshimura N.
  • Journal Title: Arch Ophthalmol Volume: 129 Pages: 1633-1635
  • Peer Reviewed
• [Presentation] High-resolution Photoreceptor Imaging of Macular Microholes Using Adaptive Optics Scanning Laser Ophthalmoscopy (2012)
  • Author(s): Ooto S, et al
  • Organizer: American Academy of Ophthalmology
  • Place of Presentation: Chicago, USA
  • Year and Date: 2012-11-11
• [Presentation] シンポジウム 眼光学から考える眼底イメージング「 Adaptive Optics」 (2012)
  • Author(s): 大音壮太郎
  • Organizer: 第66回日本臨床眼科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-26
• [Presentation] SIG 黄斑研究会シンポジウム 網膜形態評価法はどこまで進歩したか「補償光学 視細胞」 (2012)
  • Author(s): 大音壮太郎
  • Organizer: 第66回日本臨床眼科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-25
• [Presentation] 視機能研究会シンポジウム画像は機能を推し量れるか「黄斑上膜における視細胞配列異常」 (2012)
  • Author(s): 大音壮太郎
  • Organizer: 第60回日本視覚電気生理学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-10-06
• [Presentation] サブスペシャリティサンデー 後眼部疾患 網膜疾患:手術システム・診断機器の進歩「形態学的診断機器の進歩」 (2012)
  • Author(s): 大音壮太郎
  • Organizer: 第66回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-08
• [Presentation] 眼底画像診断の進歩「補償光学」 (2011)
  • Author(s): 大音壮太郎
  • Organizer: 第115回日本眼科学会総会(招待講演)
  • Place of Presentation: 東京
• [Presentation] 網脈絡膜画像解析「補償光学」 (2011)
  • Author(s): 大音壮太郎
  • Organizer: 第47回日本眼光学学会総会(招待講演)
  • Place of Presentation: 東京
• [Presentation] High-resolution Photoreceptor Imaging of Macular Microholes Using Adaptive Optics Scanning Laser Ophthalmoscopy.
  • Author(s): Ooto S
  • Organizer: American Academy of Ophthalmology
  • Place of Presentation: Chicago
• [Presentation] サブスペシャリティサンデー 後眼部疾患 網膜疾患：手術システム・診断機器の進歩「形態学的診断機器の進歩」
  • Author(s): 大音壮太郎
  • Organizer: 66回日本眼科学会総会
  • Place of Presentation: 東京
  • Invited
• [Presentation] 視機能研究会シンポジウム 画像は機能を推し量れるか「黄斑上膜における視細胞配列異常」
  • Author(s): 大音壮太郎
  • Organizer: 第60回日本視覚電気生理学会総会
  • Place of Presentation: 名古屋
  • Invited
• [Presentation] シンポジウム 眼光学から考える眼底イメージング「Adaptive Optics」
  • Author(s): 大音壮太郎
  • Organizer: 第66回日本臨床眼科学会総会
  • Place of Presentation: 京都
  • Invited
• [Presentation] SIG黄斑研究会シンポジウム 網膜形態評価法はどこまで進歩したか「補償光学 視細胞」
  • Author(s): 大音壮太郎
  • Organizer: 第66回日本臨床眼科学会総会
  • Place of Presentation: 京都
  • Invited