| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Ischemic retinopathy is one of the leading causes of visual impairment in diabetic patients. Since the number of patients with diabetic retinopathy (DR) and vision-threatening DR is expected to increase in coming years, further research on treatments and evaluation techniques for ischemic retinopathy is needed. Recently, Adaptive Optics Scanning Laser Ophthalmoscopy (AO-SLO) has enabled noninvasive and direct monitoring of photoreceptors and blood flow in real time. We used this new method to monitor the flow of erythrocyte aggregates in the retinal capillary. Erythrocyte aggregates were elongated in a time-dependent manner in the parafoveal capillaries of normal subjects and DR patients and tis elongation values were different between DR patients and normal subjects, suggesting that erythrocyte aggregates in DR patients are less brittle than those in normal subjects. Monitoring the characteristics of dark tails has promising potential for evaluating retinal hemodynamics.
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