Analysis on roles of immune modulating cytokines for strategic development of molecular therapeutics for age-related macular degeneration

• Project/Area Number: 23791984
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Tottori University
• Principal Investigator: IKEDA Yoshifumi 鳥取大学, 医学部, 助教 (10444639)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 加齢黄斑変性 / 加齢性黄斑変性 / 加齢黄斑変性症

Research Abstract

We analyzed the relationship between the levels of intraocular inflammatory cytokines and polypoidal choroidal vasculopathy (PCV), a major form of age related macular degeneration (ARMD), and found a significantly high risk was provided by elevation of IL-23, VEGF, and IL-4. To further understand molecular pathology of choroidal neovascularization (CNV), we also analyzed cytokine levels of myopic CNV patients. IL-10 provided a significantly high risk for myopic CNV. To understand inflammatory aspect of CNV, murine laser induced choroidal neovascularization model was used. Currently, our analysis on the mouse CNV model has identified the candidate target signaling molecule for ARMD using analysis of transgenic mouse strains for signaling of the molecule

Research Products

• [Journal Article] Associations of IL-23 with Polypoidal Choroidal Vasculopathy (2012)
  • Author(s): Sasaki S, Miyazaki D, Miyake K, Terasaka Y, Kaneda S, Ikeda Y., Funakoshi T, Baba T, Yamasaki A, Inoue Y.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53(7) Pages: 3424-30
  • Peer Reviewed
• [Journal Article] Assessment of real-time polymerase chain reaction detection of acanthamoeba and prognosis determinants of acanthamoeba keratitis (2012)
  • Author(s): Ikeda Y, Miyazaki D, Yakura K,Kawaguchi A, Ishikura R, Inoue Y, Mito T, Shiraishi A, Ohashi Y, Higaki S, Itahashi M, Fukuda M, Shimomura Y, Yagita K
  • Journal Title: Ophthalmology Volume: 119 Pages: 1111-1119
  • Peer Reviewed
• [Journal Article] Associations of IL-23 with Polypoidal Choroidal Vasculopathy (2012)
  • Author(s): Sasaki S, Miyazaki D, et al
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 53 Issue: 7 Pages: 3424-30
  • DOI: 10.1167/iovs.11-7913
  • Peer Reviewed
• [Journal Article] Associations of IL-23 with Polypoidal Choroidal Vasculopathy (2012)
  • Author(s): Sasaki S, Miyazaki D, Miyake K, Terasaka Y, Kaneda S, Ikeda Y, Funakoshi
  • Journal Title: Invest Ophthalmol Vis Sci Volume: In press
  • Peer Reviewed
• [Presentation] Associations of IL-10 with choroidal Neovascularization in High Myopia (2013)
  • Author(s): Yukimi Yamamoto,Dai Miyazaki, Shin-ichi Sasaki, Ken-ichiro Miyake, Shuzo Kaneda, Yoshifumi Ikeda, Atsushi Yamasaki and Yoshitsugu Inoue
  • Place of Presentation: ARVO Seattle
• [Presentation] Associations of IL-10 with choroidal Neovascularization in High Myopia (2013)
  • Author(s): Yamamoto Y
  • Organizer: ARVO
  • Place of Presentation: Seattle(WASHINGTON STATE CONVENTION CENTER)
• [Presentation] 近視性脈絡膜新生血管に対するベバシズマブ硝子体内投与後の再発と前房水中VEGF濃度 (2013)
  • Author(s): 山﨑厚志，池田欣史，他
  • Organizer: 第117回日本眼科学会総会
  • Place of Presentation: 東京（東京国際フォーラム）
• [Presentation] ポリープ状脈絡膜血管症と前房内IL-23の関連 (2012)
  • Author(s): 佐々木慎一，池田欣史，他
  • Organizer: 第51回日本網膜硝子体学会総会
  • Place of Presentation: 甲府(甲府富士屋ホテル）
• [Presentation] ポリープ状脈絡膜血管症と前房内IL-23の関連
  • Author(s): 佐々木慎一, 宮崎大,三宅賢一郎, 寺坂祐樹,金田周三,池田欣史,船越泰作, 馬場高志, 山崎厚志,井上幸次
  • Organizer: 第51回日本網膜硝子体学会総会
  • Place of Presentation: 甲府
• [Presentation] 近視性脈絡膜新生血管に対するベバシズマブ硝子体内投与後の再発と前房水中VEGF濃度
  • Author(s): 山崎厚志,宮崎 大,山本由紀美,金田周三,池田欣史,富長岳史,三宅賢一郎,井上幸次
  • Place of Presentation: 東京