Neuro protective effect of siRNA at glaucoma model rats
| Project/Area Number |
23791992
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 緑内障 / 神経保護 / siRNA / 眼科 / 虚血再灌流 / アポトーシス |
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| Research Abstract |
SiRNA(small interfering RNA) is a small molecule double-strand RNA and suppress specific gene expression. In this study, we investigated the effect of intra-vitreous injection of caspase-3 siRNA or caspase-9 siRNA against for retinal ganglion cell damage by transient ischemic injury, one of the rat's glaucoma models. In caspase-3 or caspase-9 injected eyes, loss of retinal ganglion cell was statistically smaller than the control group. Therefor capase-3 siRNA and capase-9 siRNA are expected for novel anti-glaucoma siRNA drug, prevent from retinal ganglion cell loosing by glaucoma.
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Report
(4 results)
Research Products
(8 results)
