The investigation for pathogenesis of glaucoma and the overcome of complications of filtering surgery via focusing on transthyretin

Research Project

Project/Area Number	23791993
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Ophthalmology
Research Institution	Kumamoto University
Principal Investigator	KAWAJI Takahiro 熊本大学, 医学部附属病院, 講師 (30423677)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords	家族性アミロイドポリニューロパチー / 緑内障 / トランスサイレチン / トラベクレクトミー / 国際情報交流
Research Abstract	Secondary glaucoma is the most serious ocular manifestation of transthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP). We investigated the mechanism of bleb encapsulation, which is a complication of filtering surgery. TTR-aggregated amyloid did not cause any change for fibroblast in vitro in physiolosical condition. Subconjunctival TTR-aggregated amyloid embedded in Poly-HEMA in rat might cause mild inflammation. Also, TTR concentration in aqueous humor is significantly higher and TTR is significantly oxidized in glaucomatous eyes.

Report

(3 results)