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The investigation for pathogenesis of glaucoma and the overcome of complications of filtering surgery via focusing on transthyretin

Research Project

Project/Area Number 23791993
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionKumamoto University

Principal Investigator

KAWAJI Takahiro  熊本大学, 医学部附属病院, 講師 (30423677)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords家族性アミロイドポリニューロパチー / 緑内障 / トランスサイレチン / トラベクレクトミー / 国際情報交流
Research Abstract

Secondary glaucoma is the most serious ocular manifestation of transthyretin (TTR)-related familial amyloidotic polyneuropathy (FAP). We investigated the mechanism of bleb encapsulation, which is a complication of filtering surgery. TTR-aggregated amyloid did not cause any change for fibroblast in vitro in physiolosical condition. Subconjunctival TTR-aggregated amyloid embedded in Poly-HEMA in rat might cause mild inflammation.
Also, TTR concentration in aqueous humor is significantly higher and TTR is significantly oxidized in glaucomatous eyes.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2012

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Simultaneous increases in multiple proinflammatory cytokines in the aqueous humor of pseudophakic glaucomatous eyes2012

    • Author(s)
      Inoue T, Kawaji T, Inatani M, Kameda T, Yoshimura N, Tanihara H
    • Journal Title

      Journal of Cataract and Refractive Surgery

      Volume: 38 Issue: 8 Pages: 1389-1397

    • DOI

      10.1016/j.jcrs.2012.04.028

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 平成 23 年度日本眼科学会学術奨励賞 受賞論文総説:家族性トランスサイレチン眼アミロイドーシスへの網膜光凝固術2012

    • Author(s)
      川路隆博
    • Journal Title

      日本眼科学会雑誌

      Volume: 116巻 Pages: 1046-51

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 平成23年度日本眼科学会学術奨励賞 受賞論文総説:家族性トランスサイレチン眼アミロイドーシスへの網膜光凝固術2012

    • Author(s)
      川路隆博
    • Journal Title

      日本眼科学会会誌

      Volume: 116 Pages: 1046-51

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] 家族性トランスサイレチン眼アミロイドーシスにおける網膜光凝固術の効果2012

    • Author(s)
      川路隆博
    • Organizer
      第116回日本眼科学会
    • Place of Presentation
      東京国際フォーラム、東京
    • Related Report
      2012 Annual Research Report 2012 Final Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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