| Project/Area Number |
23792000
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
|
|---|
| Research Institution | Iwate Medical University |
|---|
Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
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| Keywords | 水晶体上皮細胞 / 上皮間葉系移行 / コラーゲンゲル収縮 / TGF-β / statin |
|---|
| Research Abstract |
This study showed that lovastatin inhibits TGF -β-induced epithelial-mesenchymal transition, cellular contraction and the expression of extracellular matrix in porcine lens epithelial cells. However, high concentration lovastatin may affect the normal cellular activities. Moreover, as a mechanism of epithelial-mesenchymal transition, it has confirmed that Rho pathway was an important factor in the effect of TGF-β, Although the other pathways may participate. This suggests that lovastatin should be considered as a new agent to prevent postoperative complicationsof cataract.
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