Involvement of Angptl2 in pathogenesis of Age-relatedmacular degeneration

• Project/Area Number: 23792003
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: HIRASAWA Manabu 慶應義塾大学, 医学部, 共同研究員 (80365345)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: アンギオポイエチン様タンパク加齢黄斑変性 / アンギオポイエチン様タンパク / 加齢黄斑変性

Research Abstract

Age-related macular degeneration isthe main cause of blindness in middle age in Japan, elucidation of the new molecular mechanism is desired. We investigated the involvement of angiopoietin-like protein 2 (Angptl2) to age-related macular degeneration. In

Research Products

• [Journal Article] Neuroprotective response after photo dynamic therapy: role of vascular endo- thelial growth factor. (2011)
  • Author(s): Misa Suzuki, Yoko Ozawa, Shunsuke Kubota, Manabu Hirasawa, Seiji Miyake, Kousuke Noda, Kazuo Tsubota, Kazuaki Kadonosono, Susumu Ishida.
  • Journal Title: Journal of Neuroinflammation Volume: 8 Pages: 176-176
  • Peer Reviewed
• [Journal Article] Cyclooxygenase inhibitor improved an exudative lesion of choroidal neovascular- ization in age-related macular degene- ration (2011)
  • Author(s): Misa Suzuki, Takayoshi Suzuki, Aoi Nagano, Manabu Hirasawa, Kenichi Sakuyama, Nobuhisa Mizuki.
  • Journal Title: European journal of ophthalmology Volume: 22 Pages: 495-8
  • Peer Reviewed
• [Journal Article] フェムトセカンドレーザーによる角膜減張切開術の初期成績 (2011)
  • Author(s): 吉野真未、ビッセン宮島弘子、平沢学
  • Journal Title: 眼科手術 Volume: 25 Pages: 176-176
• [Presentation] 脈絡膜新生血管モデルにおけるAngiopoietin-like 2の関与 (2013)
  • Author(s): 平沢 学
  • Organizer: 第117回日本眼科学会総会
  • Place of Presentation: 東京
• [Presentation] Laser in situ keratomileusis後眼における多焦点眼内レンズ挿入の臨床成績 (2012)
  • Author(s): 平沢学,ビッセン宮島弘子,吉野真未,野中亮子,大木伸一, 南慶一郎
  • Organizer: 第66回日本臨床眼科学会
  • Place of Presentation: 京都
  • Year and Date: 2012-10-28
• [Presentation] 当院における多焦点眼内レンズ挿入希望例の検討 (2012)
  • Author(s): 佐藤久美子,ビッセン宮島弘子,吉野真未,平沢学,大木伸一,大熊泉
  • Organizer: 第27回日本白内障屈折矯正手術学会
  • Place of Presentation: 東京
  • Year and Date: 2012-06-17
• [Presentation] 多焦点レンズ挿入後に単焦点眼内レンズに交換した3例 (2012)
  • Author(s): 大木伸一,ビッセン宮島弘子,平沢学,吉野真未
  • Organizer: 第27回日本白内障屈折矯正手術学会
  • Place of Presentation: 東京
  • Year and Date: 2012-06-17
• [Presentation] Association of Angiopoietin-like Protein 2 with Inflammatory Signals in the Human Retinal Pigment Epithelium (2012)
  • Author(s): Hirasawa M, Endo M, Miyake S, Narimatsu T, Kubota S, Suzuki M, Ishida S, Tsubota K, Oike Y, Ozawa Y
  • Organizer: ARVO Annual Meeting Fort Lauderdale FL
  • Place of Presentation: USA
  • Year and Date: 2012-05-09
• [Presentation] The Protective Effect of AICAR on the Neural Retina during Inflammation in mice (2012)
  • Author(s): Kamoshita M, Yuki K, Kubota S, Hirasawa M, Narimatsu T, Nagai N, Tsubota K, Ozawa Y.
  • Organizer: ARVO Annual Meeting Fort Lauderdale FL
  • Place of Presentation: USA
  • Year and Date: 2012-05-09
• [Presentation] Histological Changes After Photodynamic Therapy (PDT) Combined With Anti-vascular Endothelial Growth Factor (VEGF) Therapy In The Mouse Retina (2012)
  • Author(s): Suzuki M, Kubota S, Hirasawa M, Miyake S, Noda K, Tsubota K, Kadonosono K, Ishida S, Ozawa Y.
  • Organizer: ARVO Annual Meeting Fort Lauderdale FL
  • Place of Presentation: USA
  • Year and Date: 2012-05-09
• [Presentation] 小沢洋子光線力学的療法に伴う血管内皮増殖因子の発現亢進の生物学的意義 (2012)
  • Author(s): 鈴木美砂,久保田俊介,平沢学,三宅誠司,野田航介,門之園一明,石田晋
  • Organizer: 第116回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2012-04-08
• [Presentation] フェムトセカンドレーザーによる角膜減張切開術の初期成績 (2012)
  • Author(s): 吉野真未, ビッセン宮島弘子, 平沢 学, 大木伸一, 佐藤久美子, 南 慶一郎.
  • Organizer: 第35回日本眼科手術学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-01-29
• [Presentation] Association of Angiopoietin-like Protein 2 with Inflammatory Signals in the Human Retinal Pigment Epithelium (2012)
  • Author(s): 平沢 学
  • Organizer: ARVO Annual Meeting
  • Place of Presentation: Fort Lauderdale
• [Presentation] 斜乱視例への回折型多焦点眼内レンズ挿入 (2011)
  • Author(s): 平沢学,ビッセン宮島弘子,野中亮子,大木伸一,南慶一郎
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-10
• [Presentation] SOD1ノックアウトマウスにおける網膜神経節細胞数の減少 (2011)
  • Author(s): 結城賢哉、小沢洋子、吉田哲、栗原俊英、平沢学、野田航介、石田晋、坪田一男
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-15
• [Presentation] Cytokine Regulation of Transcriptional Factor Snail in Human Retinal Pigment Epithelium (2011)
  • Author(s): Hirasawa M, Noda K, Suzuki M, Ozawa Y, Tsubota K, Ishida S.
  • Organizer: ARVO Annual Meeting Fort Lauderdale FL
  • Place of Presentation: USA
  • Year and Date: 2011-05-15
• [Presentation] Translocation of Beta-catenin In The Retinal Pigment Epithelium After Light-exposure (2011)
  • Author(s): Narimatsu T, Kubota S, Miyake S, Hirasawa M, Kurihara T, Ishida S, Ozawa Y, Tsubota K.
  • Organizer: ARVO Annual Meeting Fort Lauderdale FL
  • Place of Presentation: USA
  • Year and Date: 2011-05-15
• [Presentation] Role of Vascular Endothelial Growth Factor Induced by Photodynamic Therapy (2011)
  • Author(s): Suzuki M, Ozawa Y, Kubota S, Hirasawa M, Miyake S, Narimatsu T, Tsubota K, Kadonosono K, Noda K, Ishida S.
  • Organizer: ARVO Annual Meeting Fort Lauderdale FL
  • Place of Presentation: USA
  • Year and Date: 2011-05-15
• [Presentation] 東京歯科大学水道橋病院眼科における周術期の安全対策 (2010)
  • Author(s): 斎野泰代,平沢学,ビッセン宮島弘子,熊谷知子,大木伸一,吉野真未
  • Organizer: 第27回日本眼科看護研究会
  • Place of Presentation: 宮崎
  • Year and Date: 2010-09-11