Novel administration of anti-VEGF antibody for retinopathy of prematurity
| Project/Area Number |
23792006
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Showa University |
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Principal Investigator |
SAITO Yuta 昭和大学, 医学部, 助教 (70407477)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 薬理学 / 未熟児網膜症 / 血管内皮増殖因子 / 抗VEGF抗体 / 薬物動態 / VEGF / IGF-1 / OIR / 網膜毒性 |
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| Research Abstract |
We investigated that the effect, pharmacokinetics and toxicity of subconjunctival or intravitreal injections of anti-VEGF antibody for OIR rat model. Subconjunctival injection of anti-VEGF suppressed the retinal neovascularization in OIR rat model; even the effect was smaller than that of intravitreal injection. The antibody escapedinto systemic circulation, thus it affected fellow eyes. The toxicity for retinas was not detected.
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Report
(3 results)
Research Products
(6 results)
