Novel administration of anti-VEGF antibody for retinopathy of prematurity

• Project/Area Number: 23792006
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Ophthalmology
• Research Institution: Showa University
• Principal Investigator: SAITO Yuta 昭和大学, 医学部, 助教 (70407477)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 薬理学 / 未熟児網膜症 / 血管内皮増殖因子 / 抗VEGF抗体 / 薬物動態 / VEGF / IGF-1 / OIR / 網膜毒性

Research Abstract

We investigated that the effect, pharmacokinetics and toxicity of subconjunctival or intravitreal injections of anti-VEGF antibody for OIR rat model. Subconjunctival injection of anti-VEGF suppressed the retinal neovascularization in OIR rat model; even the effect was smaller than that of intravitreal injection. The antibody escapedinto systemic circulation, thus it affected fellow eyes. The toxicity for retinas was not detected.

Research Products

• [Journal Article] Effects of Subconjunctival Injection of Anti-Vascular Endothelial Growth Factor Antibody on Oxygen-Induced Ischemic Retinopathy in a Neonatal Rat Model (2012)
  • Author(s): Kabayama J, Saito Y, Nakanishi-Ueda T, Ueda T, Matsubara M, Wada Y, Okawada H, Hisamitsu T, Koide R
  • Journal Title: The Showa University Journal of Medical Sciences Volume: 24(1) Pages: 11-9
  • NAID: 130004566546
• [Journal Article] Effects of Subconjunctival Injection of anti-Vascular Endothelial Growth Factor Antibody on Oxygen-Induced Ischemic Retinopathy in a Neonatal Rat Model (2012)
  • Author(s): J. Kabayama
  • Journal Title: THE SHOWA UNIVERSITY JOURNAL of MEDICAL SCIENCE Volume: 24 Pages: 11-19
  • Peer Reviewed
• [Journal Article] Effects of Subconjunctival Injection of anti-Vascular Endothelial Growth Factor Antibody on Oxygen-induced Ischemic Retinopathy in a Neonatal Rat Model (2012)
  • Author(s): J. Kabayama, Y. Saito, T. Nakanishi-Ueda, T. Ueda, M. Matsubara, Y. Wada, H. Okawada, T. Hisamitsu, R. Koide
  • Journal Title: THE SHOWA UNIVERSITY JOURNAL of MEDICAL SCIENCE Volume: 24
  • NAID: 130004566546
  • Peer Reviewed
• [Presentation] Effects of Subconjunctival Injection of anti-VEGF Antibody on Oxygen-induced Retinal Neovascularization of the Neonatal Rat Model (2011)
  • Author(s): Yuta Saito, Takako Nakanishi-Ueda, Toshihiko Ueda, Yoshihiro Wada, Hajime Yasuhara, Ryohei Koide
  • Organizer: ARVO 2011 Annual Meeting
  • Place of Presentation: Fort Lauderdale
• [Presentation] 高濃度酸素負荷虚血網膜症ラットに対する抗VEGF抗体結膜下投与の効果の検討 (2011)
  • Author(s): 蒲山順吉、齋藤雄太、植田俊彦、中西孝子、松原 倫子、和田悦洋、久光正、小出良平
  • Organizer: 第31回日本眼薬理学会
  • Place of Presentation: 島根県松江市
• [Presentation] 高濃度酸素負荷虚血網膜症ラットに対する抗VEGF抗体結膜下投与の効果の検討 (2011)
  • Author(s): 蒲山順吉、齋藤雄太、植田俊彦、中西孝子、松原倫子、和田悦洋、久光正、小出良平
  • Organizer: 第３１回日本眼薬理学会
  • Place of Presentation: 島根県松江市