The role and pathophysiologic significance of IL-6 trans-signaling in the cornea
| Project/Area Number |
23792010
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Nihon University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 角膜 / IL-6 レセプター / 炎症 / 抗体 / IL-6R / トランスシグナリング / 上皮実質相互作用 / IL-6レセプター / 抗体点眼 |
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| Research Abstract |
IL-6/s (soluble)IL-6R complex can bind and activate cells in a mechanism termed IL-6 trans-signaling. We investigated the effect of IL-6R blockade on corneal inflammation. Topical instillation of anti-IL-6R antibody was applied to mice corneas with alkali burn. By IL-6R blockade, the vascularized area and inflammatory cells infiltration were significantly reduced. Expressions of phosphorylated STAT3, ICAM-1, MCP-1, and VEGF-A in the corneal stroma were significantly inhibited by IL-6R blockade. We deduce that IL-6 trans-signaling plays a significant role in ocular surface inflammationand that the blockade of IL-6R contributes to the reduction in corneal inflammation.
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Report
(3 results)
Research Products
(25 results)
