Dependence of corneal stem/progenitor cells on ocular surface innervation.
| Project/Area Number |
23792015
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
UENO Hiroki 聖マリアンナ医科大学, 医学部, 助教 (30529897)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 角膜 / 三叉神経 / 角膜 stem/progenitor 細胞 / 角膜三叉神経 / 角膜stem/progenitor細胞 / stem/progenitor 細胞 / 神経麻痺性角膜炎 |
|---|
| Research Abstract |
Trigeminal stereotactic electrolysis (TSE) was able to induce a disease state that reflected clinical neurotrophic keratitis. Moreover, corneolimbal stem/progenitor cells are significantly reduced after depletion of sensory nerves. The datasuggest a critical role of innervation in maintaining stem cells and/or the stem cell niche.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Transfection with pax6 gene of mouse embryonic stem cells and subsequent cell cloning induced retinal neuron progenitors, including retinal ganglion cell-like cells, in vitro2010
Author(s)
Maki Kayama, Manae S. Kurokawa, Yuji Ueda, Hiroki Ueno, Yuta Kumagai, Shunmei Chiba, Erika Takada, Satoki Ueno, Mamoru Tadokoro and Noboru Suzuki.
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Journal Title
Ophthalmic Res.
Volume: 43(2)
Issue: 2
Pages: 79-91
DOI
Related Report
Peer Reviewed
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