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The role for fatty acid β-oxidation system in retinal Muller cell

Research Project

Project/Area Number 23792018
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Ophthalmology
Research InstitutionFujita Health University

Principal Investigator

ATSUZAWA Kimie  藤田保健衛生大学, 医学部, 助教 (60387727)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords眼細胞生物学 / 網膜 / ミュラー細胞 / 脂肪酸β酸化
Research Abstract

The nutrient metabolism of Muller cell and retinal ganglion cell of theretina, fatty acid β-oxidation system in particular, was attempted by biological and morphologicalstudies. All the enzymes examined were shown to be present in the cultured retinal Muller cell byimmunofluorescent microscopy. Because of difficulty with establishment of the culture system ofretinal ganglion cells, primary cultured hippocampal neuron and astrocytes were attemptedalternatively. Mature neurons contain relatively small amount of fatty acid β-oxidation enzymes asthat of the liver tissue. The present results are helpful in elucidating the energy production systemin the retina.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 1 results) Presentation (10 results)

  • [Journal Article] Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.2013

    • Author(s)
      Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T.
    • Journal Title

      Neuropsychopharmacology

      Volume: 38(8) Issue: 8 Pages: 1409-25

    • DOI

      10.1038/npp.2013.38

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of JAK-STAT3 signaling pathway in chronic subdural hematoma outer membranes.2013

    • Author(s)
      Koji Osuka 他
    • Journal Title

      Neuroscience Letters

      Volume: 534 Pages: 166-170

    • DOI

      10.1016/j.neulet.2012.11.011

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activation of Ras/MEK/ERK signaling in chronic subdural hematoma outer membranes.2012

    • Author(s)
      Koji Osuka 他
    • Journal Title

      Brain Research

      Volume: 1489 Pages: 98-103

    • DOI

      10.1016/j.brainres.2012.10.013

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of STAT1 in neurons following spinal cord injury in mice.2011

    • Author(s)
      Osuka K, Watanabe Y, Usuda N, Atsuzawa K, Yasuda M, Aoshima C, Wakabayashi T, Takayasu M.
    • Journal Title

      Neurochem Res

      Volume: 36 Issue: 12 Pages: 2236-2243

    • DOI

      10.1007/s11064-011-0547-6

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Activation of PI3 kinase/Akt signaling in chronic subdural hematoma outer membranes.2011

    • Author(s)
      Funai M, Osuka K, Usuda N, Atsuzawa K, Inukai T, Yasuda M, Watanabe Y, Takayasu M.
    • Journal Title

      J Neurotrauma

      Volume: 28 Issue: 6 Pages: 1127-1131

    • DOI

      10.1089/neu.2010.1498

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] ミトコンドリア脂肪酸β酸化系酵素の初代培養細胞における免疫組織化学と in vitro probe assay による解析2013

    • Author(s)
      厚沢季美江
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      高松
    • Year and Date
      2013-03-28
    • Related Report
      2012 Final Research Report
  • [Presentation] 培養網膜ミュラー細胞の免疫組織化学2012

    • Author(s)
      厚沢季美江
    • Organizer
      第72回日本解剖学会中部支部学術集会
    • Place of Presentation
      岐阜
    • Year and Date
      2012-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 追加発言:ミトコンドリの臓器差-網膜の免疫組織化学-2012

    • Author(s)
      厚沢季美江
    • Organizer
      第117回日本解剖学会全国学術集会
    • Place of Presentation
      甲府
    • Year and Date
      2012-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] ミトコンドリアの臓器差ー網膜の免疫組織化学ー2012

    • Author(s)
      厚沢季美江
    • Organizer
      第117回日本解剖学会全国学術集会 シンポジウム「新しく開かれるミトコンドリアの構造と機能」(招待講演)
    • Place of Presentation
      山梨大学
    • Related Report
      2011 Research-status Report
  • [Presentation] 組織内「微小環境栄養学」-網膜におけるミトコンドリア脂肪酸β酸化系酵素の免疫組織化学的局在2011

    • Author(s)
      厚沢季美江
    • Organizer
      第71回日本解剖学会中部支部学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 組織内「微小環境栄養学」ー網膜における脂肪酸β酸化系酵素の免疫組織化学的局在ー2011

    • Author(s)
      厚沢季美江、松澤綾美、深澤元晶、橋本隆、臼田信光
    • Organizer
      平成23年度第71回日本解剖学会中部支部学術集会
    • Place of Presentation
      名古屋大学
    • Related Report
      2011 Research-status Report
  • [Presentation] ミトコンドリア脂肪酸β酸化系酵素の初代培養細胞における免疫組織化学とin vitro probe assay による解析

    • Author(s)
      厚沢季美江、松澤綾美、深澤元晶、古居みどり、山口清次、臼田信光
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      高松
    • Related Report
      2012 Annual Research Report
  • [Presentation] ミトコンドリア脂肪酸β酸化系酵素HADH2の免疫組織化学

    • Author(s)
      厚沢季美江、深澤元晶、臼田信光
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      高松
    • Related Report
      2012 Annual Research Report
  • [Presentation] 培養Sertoli細胞の免疫組織化学

    • Author(s)
      深澤元晶、厚沢季美江、松澤綾美、橋本隆、臼田信光
    • Organizer
      第72回日本解剖学会中部支部学術集会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 培養網膜ミュラー細胞の免疫組織化学

    • Author(s)
      厚沢季美江、松澤綾美、深澤元晶、橋本隆、臼田信光
    • Organizer
      第72回日本解剖学会中部支部学術集会
    • Place of Presentation
      岐阜
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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