Research Project
Grant-in-Aid for Young Scientists (B)
We previously showed that neuron-specific Dock3, a new member of the guanine nucleotide exchange factors for the small GTPase Rac1, induces axonal outgrowth in retinal ganglion cells (RGCs). In this study, we found that Dock3 protects RGCs from both glutamate neurotoxicity and oxidative stress. We also demonstrated that Dock3 overexpression prevents glaucomatous retinal degeneration in GLAST deficient mice, a model of normal tension glaucoma.
All 2013 2012 2011 Other
All Journal Article (13 results) (of which Peer Reviewed: 6 results) Presentation (5 results) Remarks (1 results)
Cell Death Differ.
Volume: 20 Issue: 2 Pages: 270-280
10.1038/cdd.2012.122
日眼会誌
Volume: 117(2) Pages: 161-161
日本眼科学会雑誌
Volume: 117 Pages: 161-161
Genes to Cells.
Volume: 17 Issue: 8 Pages: 688-697
10.1111/j.1365-2443.2012.01616.x
Journal of Neuroscience
Volume: 32 Issue: 1 Pages: 264-274
10.1523/jneurosci.4884-11.2012
Volume: 116(5) Pages: 527-527
Volume: 116 Pages: 527-527
Nature Communications
Volume: 2 Issue: 1 Pages: 1-9
10.1038/ncomms1190
Investigative Ophthalmology & Visual Science
Volume: 52(5) Issue: 5 Pages: 2696-2703
10.1167/iovs.10-6015
Volume: 115(8) Pages: 729-729
Volume: 115(7) Pages: 637-637
Volume: 115(5) Pages: 485-485
Cell Death and Differentiation
Volume: (in press)
http://www.igakuken.or.jp/retina/