New therapy for glaucoma and optic neuritis using Dock3
| Project/Area Number |
23792024
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Ophthalmology
|
|---|
| Research Institution | 公益財団法人東京都医学総合研究所 (2012)
Tokyo Metropolitan Organization for Medical Research (2011) |
|---|
Principal Investigator |
KIMURA Atsuko 公益財団法人東京都医学総合研究所, 運動・感覚システム研究分野, 研究員 (60569143)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
|---|
| Keywords | Dock3 / 緑内障 / 視神経炎 / 神経変性 / 神経細胞死 / 脱髄 / オリゴデンドロサイト |
|---|
| Research Abstract |
We previously showed that neuron-specific Dock3, a new member of the guanine nucleotide exchange factors for the small GTPase Rac1, induces axonal outgrowth in retinal ganglion cells (RGCs). In this study, we found that Dock3 protects RGCs from both glutamate neurotoxicity and oxidative stress. We also demonstrated that Dock3 overexpression prevents glaucomatous retinal degeneration in GLAST deficient mice, a model of normal tension glaucoma.
|
Report
(3 results)
Research Products
(19 results)
-
[Journal Article] Inhibition of ASK1-p38 pathway prevents neural cell death following optic nerve injury.2013
Author(s)
Katome, T., Namekata, K., Guo, X., Semba, K., Kittaka, D., Kawamura, K., Kimura, A., Harada, C., Ichijo, H., Mitamura, Y. and Harada, T.
-
Journal Title
Cell Death Differ.
Volume: 20
Issue: 2
Pages: 270-280
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Journal Article] Spermidine alleviates severity of murine experimental autoimmune encephalomyelitis2011
Author(s)
Guo, X., Harada, C., Namekata, K., Kimura, A., Mitamura, Y., Yoshida, H., Matsumoto, Y., and Harada, T
-
Journal Title
Investigative Ophthalmology & Visual Science
Volume: 52(5)
Issue: 5
Pages: 2696-2703
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Dock3 attenuates neural cell death due to NMDA neurotoxicity and oxidative stress in a mouse model of normal tension glaucoma
Author(s)
Namekata, K., Kimura, A., Kawamura, K., Guo, X., Harada, C., Tanaka, K. and Harada, T
-
Journal Title
Cell Death and Differentiation
Volume: (in press)
Related Report
Peer Reviewed
-
-
-
-
-
-
