| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We planned to examine whether adipose derived stem cells (ADSC) could surpass bone marrow derived stem cells (BMSC) for donor ability. Both of them were inducted in osteoinduction medium within scaffolds, and transferred into bone defect respectively that we made on rabbits' mandible. After 4weeks, we harvested the tissues, both of defects showed less fibrosis compared with control group, but we didn't detect significant differences between them statistically. Moreover neither of ADSC nor MSC provided more bone remodeling than controls. That lead us to the investigation that we should consider the term for osteo-induction in vitro and the fact transfer groups prevented defect fibrosis means this methods could be an effective step to prevent bone regression in clinical cases after osteodistruction surgery of infants suffering midface anomary.
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