Development of novel composite tissue allograft models using supermicrosurgery

• Project/Area Number: 23792039
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: The University of Tokyo
• Principal Investigator: IIDA Takuya 東京大学, 医学部附属病院, 特任講師 (00398603)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 組織移植 / 同種複合組織移植 / 超微小血管吻合 / 同種移植

Research Abstract

Novel composite tissue allograft animal models were developed using the supermicrosurgical techniques. We focused on mainly two models as follows; eye transplantation model using rabbits and uterus transplantation model using cynomolgus monkeys. Several problems in application of these models to clinical cases were noted such as optic nerve regeneration in eye model and pregnancy in uterus model, and thus several experiments were performed to solve these problems.

Research Products

• [Journal Article] vascularized nerve flapこれまでの臨床経験 (2013)
  • Author(s): 菊池和希(東京大学医学部形成外科),三原
  • Journal Title: 脳神経外科速報(0917-1495) Volume: 23巻3号 Pages: 283-289
• [Journal Article] Pathological steps of cancer-related lymphedema: histological changes in the collecting lymphatic vessels after lymphadenectomy (2012)
  • Author(s): Mihara M, Hara H, Hayashi Y, Narushima M, Yamamoto T, Todokoro T, Iida T, Sawamoto N, Araki J, Kikuchi K, Murai N, Okitsu T, Kisu I, Koshima I
  • Journal Title: PLoS One Volume: 7(7)
• [Journal Article] Uterine autotransplantation in cynomolgus macaques: the first case of pregnancy and delivery (2012)
  • Author(s): Mihara M, Kisu I, Hara H, Iida T, Araki J, Shim T, Narushima M, Yamamoto T, Moriguchi H, Kato Y, Tonsho M, Banno K,Aoki D, Suganuma N, Kagawa N, Takehara Y, Kato O, Koshima I
  • Journal Title: Hum Reprod Volume: 27(8) Pages: 2332-40
• [Journal Article] Indocyanine green fluorescence imaging for evaluation of uterine blood flow in cynomolgus macaque (2012)
  • Author(s): Kisu I, Banno K, Mihara M, Lin LY, Tsuji K, Yanokura M, Hara H, Araki J, Iida T, Abe T, Kouyama K, Suganuma N, Aoki D
  • Journal Title: PLoS One Volume: 7(4)
• [Journal Article] A new surgical technique of uterineauto-transplantation in cynomolgus monkey:preliminary report about two cases (2012)
  • Author(s): Kisu I, Mihara M, Banno K, Hara H, Yamamoto T, Araki J, Iida T, Hayashi Y, Moriguchi H, Aoki D
  • Journal Title: Arch Gynecol Obstet Volume: 285(1) Pages: 129-37
• [Journal Article] Versatility of a near-infrared vein visualization device in plastic and reconstructive surgery (2012)
  • Author(s): Iida T, Mihara M, Yoshimatsu H, Hara H, Narushima M, Koshima I
  • Journal Title: Plast Reconstr Surg Volume: 130(4)
• [Journal Article] Supermicrosurgery(解説/特集) (2012)
  • Author(s): 光嶋勲,成島三長,山本匠,関征央,菊池
  • Journal Title: 形成外科(0021-5228) Volume: 55巻9号 Pages: 975-981
• [Journal Article] Uterus autotransplantation in cynomolgus macaques: intraoperative evaluation of uterine blood flow using indocyanine green (2011)
  • Author(s): Mihara M, Kisu I, Hara H, Iida T, Yamamoto T, Araki J, Hayashi Y, Moriguchi H, NarushimaM, Banno K, Suganuma N, Aoki D, Koshima I
  • Journal Title: Hum Reprod Volume: 26(11) Pages: 3019-27
• [Journal Article] Current status of surrogacy in Japan and uterine transplantation research (2011)
  • Author(s): Kisu I, Banno K, Mihara M, Iida T, YoshimuraY
  • Journal Title: Eur J Obstet Gynecol Reprod Biol Volume: 158(2) Pages: 135-40
• [Presentation] 超微小血管吻合技術を用いた眼球移植・視神経再生モデルの開発 (2012)
  • Author(s): 飯田拓也、菊池和希、荒木淳、三原誠、光嶋勲
  • Organizer: 日本形成外科学会基礎学術集会
  • Place of Presentation: 福島
• [Presentation] 遊離組織移植におけるICG近赤外線カメラの有用性 (2011)
  • Author(s): 飯田拓也、三原誠、戸所健ほか
  • Organizer: 日本形成外科学会基礎学術集会
  • Place of Presentation: 新宿
  • Year and Date: 2011-10-06
• [Presentation] 頭蓋底悪性腫瘍に対する治療 最近の動向と進歩 (2011)
  • Author(s): 飯田拓也
  • Organizer: 日本頭蓋底外科学会
  • Place of Presentation: 大阪