A genome-wide association study for keloid disease and functional analysis of keloid candidate genes

• Project/Area Number: 23792040
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Yokohama City University (2012); The University of Tokyo (2011)
• Principal Investigator: NAKASHIMA Mitsuko 横浜市立大学, 医学部, 助教 (20541965)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: GWAS / non-coding RNA / マイクロアレイ / Wnt signaling / ケロイド / FOXL2 / コラーゲン

Research Abstract

We carried out multi-stage genome-wide association study and identified four susceptible loci to keloid. Among the four loci, we identified the new long non-coding RNA genes in one locus. These genes showed higher expression in keloid tissues than normal skin tissues and contributed to accelerate the fibroblast cell proliferation. Microarray analysisrevealed these genes involved in keloid formation through Wnt signaling pathway

Research Products

• [Journal Article] ケロイド (2013)
  • Author(s): 中島光子、前佛均
  • Journal Title: Surgery Frontier Volume: Vol20、No.2(印刷中)
• [Journal Article] ゲノム多様性と希少疾患 (2013)
  • Author(s): 中島光子、松本直通
  • Journal Title: 細胞 Volume: vol45、No.3 Pages: 24-27
• [Journal Article] ケロイド (2013)
  • Author(s): 中島 光子
  • Journal Title: Surgery Frontier Volume: 20-2
• [Journal Article] ゲノムワイド関連解析を用いた日本人ケロイド疾患感受性領域の同定 (2012)
  • Author(s): 中島光子、前佛均
  • Journal Title: Aesthetic Dermartology Volume: Vol.22、No.2 Pages: 79-89
  • Peer Reviewed
• [Journal Article] ゲノムワイド関連解析を用いた日本人ケロイド疾患感受性領域の同定 (2012)
  • Author(s): 中島 光子
  • Journal Title: Aethetic Dermatology Volume: 22 Pages: 79-89
  • Peer Reviewed
• [Presentation] 遺伝的多型に基づくケロイド新規疾患感受性遺伝子の同定および機能解析 (2012)
  • Author(s): 中島光子
  • Organizer: 日本人類遺伝学会
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] 遺伝的多型に基づくケロイド新規疾患感受性遺伝子の同定および機能解析 (2012)
  • Author(s): 中島 光子
  • Organizer: 日本人類遺伝学会
  • Place of Presentation: 京王プラザホテル (東京都)
• [Presentation] A genome-wide association study for keloid disease and involvement of FOXL2 in keloid formation. (2011)
  • Author(s): 中島 光子
  • Organizer: 日本人類遺伝学会
  • Place of Presentation: 千葉県