The role of Rho/Rho kinase in wound healing

Research Project

Project/Area Number	23792043
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Plastic surgery
Research Institution	Osaka University
Principal Investigator	KANAZAWA Shigeyuki 大阪大学, 医学系研究科, 助教 (50506243)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	創傷治癒学 / 創傷治癒
Research Abstract	Rho kinse-inhibited cells increased the migration rate as compared to the control cells in the wound healing assay. Moreover, Rho kinase-inhibited cells showed activation of cofilinin western blotting. Inhibition of Rho kinase promoted cell migration and wound healing in DM model mouse. These data showed that inhibition of Rho kinase have positive effects in wound healing.

Report

(3 results)