| Project/Area Number |
23792049
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | 臍帯由来間葉系幹細胞 / 口唇口蓋裂 / 臍帯血由来間葉系幹細胞 / 間葉系幹細胞 / 唇顎口蓋裂 / 顎裂 / 歯肉骨膜形成術 / Gingivoperiosteoplasty / 骨再生 |
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| Research Abstract |
Prenatal diagnosis of cleft lip and palate is accurate. We investigated the clinical applicability of umbilical cord-derived mesenchymal stem cells harvested at birth for primary gingivoperiosteoplasty and bone grafting 3 to 6 months after birth. Secondary bone grafting, which is usually performed when the patient is 5 to 10 years old using iliac cancellous bone, provides good results.
Our findings revealed that the quality of umbilical cord-derived mesenchymal stem cells differed from that of iliac cancellous bone-derived mesenchymal stem cells, because differentiation of umbilical cord-derived mesenchymal stem cells into bone cells was difficult to achieve. We detected no difference between the bone formations in the umbilical cord-derived mesenchymal stem cell graft model and those of the non-cell graft model using the nude mouse with partial maxillary defects. Studies of the recipient niche might be as important as the cell quality.
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