Elucidation of the dynamic interaction with the cell - cell adhesion and the cell - extracellular matrix adhesion in the epidermal keratinocytes.
| Project/Area Number |
23792050
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Osaka City University |
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Principal Investigator |
TATEISHI CHIHARU 大阪市立大学, 医学(系)研究科(研究院), 講師 (40597308)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 細胞―細胞接着 / 細胞―細胞外マトリックス接着 / 細胞―細胞外マトリクス接着 / 細胞-細胞接着細 / 細胞-細胞外マトリクス接着 / live cell imaging / ヘミデスモゾーム / 細胞-細胞接着 |
|---|
| Research Abstract |
The purpose of our study is to examine the dynamic interaction of cell - cell adhesion and cell - extracellular matrix adhesion in the epidermal keratinocytes. We used live cell imaging method with confocal laser microscope. We made dual transfection alpha - actinin of focal adhesion protein (CFP) plasmid and beta4 integrin of hemidesmosome (YFP) plasmid in normal human epidermal keratinocytes to visualize targets of extracellular matrix adhesion. We investigated methods how to inhibit cell - cell adhesion.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Successful treatment of betamethasone syrup on autoimmune esophagitis2014
Author(s)
Kohata Y, Fujiwara Y, Kato K, Tanaka F, Yamagami H, Tanigawa T, Shiba M, Watanabe K, Watanabe T, Tominaga K, Tateishi C, Tsuruta D, Arakawa T
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Journal Title
Am J Gastroenterol
Volume: 109(3)
Pages: 451-453
Related Report
Peer Reviewed
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[Journal Article] Three cases of linear IgA/IgG bullous dermatosis showing IgA and IgG reactivity with multiple antigens, particularly laminin-3322013
Author(s)
Sakaguchi M, Bito T, Oda Y, Kikusawa A, Nishigori C, Munetsugu T, Yokozeki H, Itotani Y, Niguma T, Tsuruta D, Tateishi C, Ishii N, Koga H, Hashimoto T
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Journal Title
JAMA Dermatol
Volume: 149(11)
Pages: 1308-1313
Related Report
Peer Reviewed
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