The function of T cell for hypertrophic scar by using animal model
| Project/Area Number |
23792055
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-28 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 創傷治癒 / 肥厚性瘢痕 / ケロイド |
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| Outline of Final Research Achievements |
As macroscopic views of the scar of the mouse, the wound of 14 days after wound making was like hypertrophy. This chage could be confirmed until 28 days. After 28days, the wound was going to be gradually relieved. The scar was harvested, and immunostained, it was recognized the expression of the T cell in predominance in the hyperplastic scar model group that burdened the tension in comparison with a normal scar. This result was obtained the pig scar model whoich skin contructure was near to Homo sapiens. Therefore, gave the Suplatast tosilate which controlled the expression of T cell, and tried the formation of the scar, but the formation of the hyperplastic scar was not recognized.
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Report
(5 results)
Research Products
(10 results)
