The influence of human adipose-derived stem cells against Squamous Cell Carcinoma

• Project/Area Number: 23792064
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: Juntendo University (2012-2013); Nippon Medical School (2011)
• Principal Investigator: TOBITA Morikuni 順天堂大学, 医学部, 助教 (10599038)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脂肪組織幹細胞 / 扁平上皮癌 / 動物実験

Research Abstract

This research was to investigate the influence of adipose-derived stem cells (ASCs) against the tumor development of squamous cell carcinoma (SCC) cells. SCC cells with or without ASCs have been transplanted into the abdominal subcutaneous tissue of experimental animals. The experimental groups were prepared as follows; 1: SCC cells transplantation; 2: Co-transplantation of SCC cells with ASCs; 3: SCC cells and ASCs transplantation into different site; and 4: SCC cells transplantation and ASCs administration. After 12 weeks of cells injection, no significant differences for the tumor development were seen between the SCC cells transplantation and other co-transplantation groups.

Research Products

• [Journal Article] Adipose-derived stem cells and periodontal tissue engineering (2013)
  • Author(s): Tobita M, Mizuno H
  • Journal Title: Int J Oral Maxillofac Implants Volume: 28
  • Peer Reviewed
• [Journal Article] Adipose-derived Stem Cells and Platelet-Rich Plasma : The Keys to Functional Periodontal Tissue Engineering (2013)
  • Author(s): Tobita M, Mizuno H
  • Journal Title: Curr Stem Cell Res Ther Volume: 8 Pages: 400-406
  • Peer Reviewed
• [Journal Article] Concentration of PDGF-AB, BB and TGF-β1 as valuable human serum parameters in adipose-derived stem cell proliferation (2013)
  • Author(s): Josh F, Tobita M, Tanaka R, Orbay H, Ogata K, Suzuki K, and Mizuno H
  • Journal Title: J Nippon Med Sch Volume: 80 Pages: 140-147
  • NAID: 130004147215
• [Journal Article] Adipose-derived stem cells and periodontal tissue engineering. (2013)
  • Author(s): Tobita M, Mizuno H
  • Journal Title: Int J Oral Maxillofac Implants. Volume: 28 Issue: 6 Pages: e487-e493
  • DOI: 10.11607/jomi.te29
  • Peer Reviewed
• [Journal Article] Adipose-derived stem cells and platelet-rich plasma: the keys to functional periodontal tissue engineering. (2013)
  • Author(s): Tobita M, Mizuno H
  • Journal Title: Curr Stem Cell Res Ther. Volume: 8 Pages: 400-406
  • Peer Reviewed
• [Journal Article] Concentration of PDGF-AB, BB and TGF-β1 as valuable human serum parameters in adipose-derived stem cell proliferation. (2013)
  • Author(s): Josh F, Tobita M, Tanaka R, Orbay H, Ogata K, Suzuki K, and Mizuno H.
  • Journal Title: J Nippon Med Sch. Volume: 80 Pages: 140-147
  • NAID: 130004147215
  • Peer Reviewed
• [Journal Article] Accelerated and safe proliferation of human adipose-derived stem cells in medium supplemented with human serum (2012)
  • Author(s): Josh F, Kobe K, Tobita M, Tanaka R, Suzuki K, Ono K, Hyakusoku H and Mizuno H
  • Journal Title: J Nippon Med Sch Volume: 79 Pages: 444-452
  • NAID: 130004057404
• [Journal Article] Mesenchymal stem cells isolated from adipose and other tissues : basic biological properties and clinical applications (2012)
  • Author(s): Orbay H, Tobita M, Mizuno H
  • Journal Title: Stem Cells Int Volume: 2012 Pages: 461718-461718
• [Journal Article] Adipose-derived stem cells as a novel tool for future regenerative medicine (2012)
  • Author(s): Mizuno H, Tobita M, Uysal AC
  • Journal Title: Stem Cells Volume: 30 Pages: 804-810
• [Journal Article] Accelerated and Safe Proliferation of Human Adipose-derived Stem Cells in Medium Supplemented with Human Serum (2012)
  • Author(s): Josh F, Kobe K, Tobita M, Tanaka R, Suzuki K, Ono K, Hyakusoku H, Mizuno H
  • Journal Title: Journal of Nippon Medical School Volume: 79 Issue: 6 Pages: 444-452
  • DOI: 10.1272/jnms.79.444
  • NAID: 130004057404
  • ISSN: 1345-4676, 1347-3409
  • Peer Reviewed
• [Journal Article] Mesenchymal stem cells isolated from adipose and other tissues: basic biological properties and clinical applications. (2012)
  • Author(s): Orbay H, Tobita M, Mizuno H.
  • Journal Title: Stem Cells Int Volume: 2012 Pages: 461718-461718
  • DOI: 10.1155/2012/461718
  • Peer Reviewed
• [Journal Article] Adipose-derived stem cells as a novel tool for future regenerative medicine (2012)
  • Author(s): Mizuno H, Tobita M, Uysal AC
  • Journal Title: Stem Cells Volume: 30 Issue: 5 Pages: 804-810
  • DOI: 10.1002/stem.1076
  • Peer Reviewed
• [Presentation] 硬組織再生における脂肪組織幹細胞と多血小板血漿混合物の相乗効果 (2013)
  • Author(s): 田島聖士、飛田護邦、水野博司
  • Organizer: 第22回日本形成外科学会基礎学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2013-11-08
• [Presentation] 歯周病予防対策としての歯槽骨再生治療の最前線 (2013)
  • Author(s): 飛田護邦
  • Organizer: 第15回日本骨粗鬆症学
  • Place of Presentation: 大阪
  • Year and Date: 2013-10-12
• [Presentation] 歯周病予防対策としての歯槽骨再生治療の最前線 (2013)
  • Author(s): 飛田護邦
  • Organizer: 第15回日本骨粗鬆症学会 骨ドック・健診分科会
  • Place of Presentation: 大阪国際会議場
  • Invited
• [Presentation] 硬組織再生における脂肪組織幹細胞と多血小板血漿混合物の相乗効果． (2013)
  • Author(s): 田島聖士、飛田護邦、水野博司
  • Organizer: 第22回日本形成外科学会基礎学術集会
  • Place of Presentation: 新潟コンベンションセンター
• [Presentation] 新鮮ヒト血清と保存ヒト血清を用いたヒト脂肪組織幹細胞の培養時における細胞増殖能の比較検証 (2012)
  • Author(s): 飛田護邦、Fonny Josh、田中里佳、緒方花澄、水野博司
  • Organizer: 第42回日本創傷治癒学会
  • Place of Presentation: 札幌
  • Year and Date: 2012-12-05
• [Presentation] 新鮮ヒト血清と保存ヒト血清を用いたヒト脂肪組織幹細胞の培養時にお ける細胞増殖能の比較検証 (2012)
  • Author(s): 飛田護邦、Fonny Josh、田中里佳、緒方花澄、水野博司
  • Organizer: 第42回日本創傷治癒学会
  • Place of Presentation: 札幌
• [Presentation] 脂肪組織幹細胞の歯科領域への応用 (2011)
  • Author(s): 飛田護邦
  • Organizer: 第53回歯科基礎医学会学術大会・総
  • Place of Presentation: 岐阜
  • Year and Date: 2011-10-01
• [Presentation] 脂肪組織幹細胞の歯科領域への応用 (2011)
  • Author(s): 飛田護邦
  • Organizer: 第53回歯科基礎医学会(招待講演)
  • Place of Presentation: 長良川国際会議場