Exper imental model of pharyngol aryngectomy and free jejunal transfer in rats

• Project/Area Number: 23792067
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Plastic surgery
• Research Institution: National Cancer Center Japan
• Principal Investigator: MIYAMOTO Shimpei 独立行政法人国立がん研究センター, 中央病院, 科長 (00407040)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 再建外科学 / マイクロサージェリー学 / 頭頸部癌 / 下咽頭癌 / 咽頭喉頭摘出 / 遊離空腸移植 / 動物モデル

Research Abstract

We developed an experimental model of pharyngolaryngectomy and free jejunal transfer in rats. We found that ileum is more suitable for transfer than jejunum. We performed pharyngolaryngectomy and free ileal transfer in three rats. The ileum could be revascularlized in all rats; however, no rat could survive for a long period. The results of this study revealed that this operation is too invasive for rats.