| Project/Area Number |
23792070
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Tokyo Women's Medical University (2013)
Chiba University (2011-2012) |
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Principal Investigator |
KIMURA TOMONORI 東京女子医科大学, 医学部, 医療練士研修生 (90598236)
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| Research Collaborator |
WATANABE Eizo 千葉大学, 大学院医学研究科, 准教授 (40375639)
ODA Shigeto 千葉大学, 大学院医学研究科, 教授 (90204205)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 重症敗血症 / オートファジー / 遺伝子多型 / severe sepsis / IL-1ra VNTR / 重症感染症 / Autophagy / SIRS / 炎症性サイトカイン |
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| Research Abstract |
We examined the association between autophagy-related IRGM (human immunity-related GTPase) polymorphism and clinical course/outcome in patients with severe sepsis. We have set the 2 cohorts and lipopolysaccharide challenge of whole blood from randomly selected healthy volunteers was performed for comparison of IRGM mRNA expression among different genotypes. When mortality were compared, no significant difference was observed in the non-sepsis group, while TT homozygotes exhibited a significantly higher mortality than that of the CC+CT genotype category in the severe sepsis group for both cohorts. Lipopolysaccharide challenge showed a significant suppression of IRGM mRNA expression in TT homozygotes compared with that of the CC+CT genotype category. The data suggest that IRGM(+313) SNP, an autophagy-related polymorphic locus, influences outcome in patients with severe sepsis, with the possible involvement of autophagy in sepsis exacerbation.
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