| Project/Area Number |
23792081
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
HASHIMOTO Soshi 京都府立医科大学, 医学(系)研究科(研究院), 助教 (60515279)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 急性肺損傷 / 急性呼吸窮迫症候群 / 人工呼吸 / 上皮間葉転換 / 上皮間葉形質転換 |
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| Research Abstract |
We have established a mouse model of acute lung injury by unilateral intratracheal instillation of hydrochloric acid. In lung histological analyses, we observed increased inflammatory cell infiltration, edema formation, and hemorrhages at 24 hours after instillation, and the development of pulmonary fibrosis at 14 days after instillation. However, we were not able to identify the mechanisms of epithelial-mesenchymal interactions in epithelial repair processes during acute lung injury. In the meantime, we found out recombinant thrombomodulin tended to prevent the development of lung fibrosis in histological analysis, suggesting that its effect might contribute to involve epithelial repair processes during acute lung injury.
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