Detection of the role of High Mobility Group Box-1 and development the treatment on septic lung injury mice after surgical invasion.

• Project/Area Number: 23792085
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Keio University
• Principal Investigator: ABE Shinya 慶應義塾大学, 医学部, 助教 (20383896)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: HMGB-1 / two hit model / サイトカイン / 敗血症性ショック / burn injury

Research Abstract

In two hit model: 15% body surface area 3rd degree burn injured mice and added CD3 stimulation or LPS stimulation 11days after burn injury,Th17 cell increased in mice intestine on 11days after burn injury, by the analysis about intestinal lymphoid cell af