Immunoanalysis of severe septic patients in the elderly and therapeutic potential of IL-15

• Project/Area Number: 23792088
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: Tokai University
• Principal Investigator: INOUE Shigeaki 東海大学, 創造科学技術研究機構, 講師 (30582209)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 高齢者 / 敗血症 / 免疫 / IL-15 / 老化 / T細胞

Research Abstract

Reduction of immunocompetent T cells followed byprolonged lymphopenia may be associated with poor prognosis in elderly septic patients.IL-15 reactivates exhausted T cells and improves survival of sepsis in aged mice.

Research Products

• [Journal Article] Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly (2013)
  • Author(s): Inoue S, Suzuki-Utsunomiya K, Okada Y, Iida Y, Taira T, Miura N, Tsuji T, Yamagiwa T, Morita S, Chiba T, Sato T, Inokuchi S
  • Journal Title: Crit Care Med Volume: 41 Pages: 810-819
  • Peer Reviewed
• [Journal Article] Reduction of Immunocompetent T Cells Followed by Prolonged Lymphopenia in Severe Sepsis in the Elderly (2013)
  • Author(s): Inoue, S.
  • Journal Title: Crit Care Med Volume: 41 Issue: 3 Pages: 810-819
  • DOI: 10.1097/ccm.0b013e318274645f
  • Peer Reviewed
• [Presentation] Prolonged hypothermia and hypercytokinemia with apoptosis of lymphocytes in aged septic mice (2013)
  • Author(s): Shigeaki Inoue
  • Organizer: Society of Critical Care Medicine’s 42nd Critical Care Congress
  • Place of Presentation: 米国 プエルトリコ サンファン
• [Presentation] 本邦のショック領域からのクリニカルトライアルを目指して (2013)
  • Author(s): 井上 茂亮
  • Organizer: 第28回日本Shock学会総会
  • Place of Presentation: 東京都港区
  • Invited
• [Presentation] Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly (2013)
  • Author(s): Shigeaki Inoue
  • Organizer: 36th Annual Conference on Shock
  • Place of Presentation: 米国 サンディエゴ
  • Invited
• [Presentation] Interleukin 15 reverses age-related CD8+ T cell inactivation with increasing interferon-gamma production and improves survival in aged septic mice (2013)
  • Author(s): Shigeaki Inoue
  • Organizer: 15th International Congress of Immunology
  • Place of Presentation: イタリア ミラノ
• [Presentation] Interleukin 15 reverses age-related T cell inactivation with increasing interferon-gamma and pSTAT3/5 production, and promotes T cell proliferation from septic patients in the elderly (2013)
  • Author(s): Shigeaki Inoue
  • Organizer: 15th Congress of the European Shock Society
  • Place of Presentation: オーストリア ウィーン
  • Invited
• [Presentation] (2012)
  • Author(s): Inoue S, Suzuki-Utsumoniya K, Komori Y, Sato T, Inokuchi S
  • Organizer: 日本外科代謝栄養学会第49回学術集会日韓合同シンポジウム講演
  • Place of Presentation: 千葉
  • Year and Date: 2012-07-06
• [Presentation] 高齢者敗血症における末梢血単核球の免疫機能解析 (2012)
  • Author(s): 井上茂亮 鈴木恭子 小森由香子 井口貞樹
  • Organizer: 第39回日本集中治療医学会学術集会
  • Place of Presentation: 千葉 幕張メッセ
• [Presentation] 高齢マウス敗血症モデルにおける免疫抑制のメカニズムを探る。 (2012)
  • Author(s): 井上 茂亮
  • Organizer: 第27回日本Shock学会総会
  • Place of Presentation: 東京都千代田区
• [Presentation] 高齢者敗血症における免疫機能解析 (2012)
  • Author(s): 井上 茂亮
  • Organizer: 第27回日本Shock学会総会
  • Place of Presentation: 東京都千代田区
• [Presentation] Reduction and functional impairment of T cells in severe sepsis in the elderly (2012)
  • Author(s): Shigeaki Inoue
  • Organizer: 第49回日本外科代謝栄養学学術集会
  • Place of Presentation: 千葉県浦安市
  • Invited
• [Presentation] Increased apoptosis of lymphocytes and prolonged cytokinemia in aged mice with sepsis (2012)
  • Author(s): Shigeaki Inoue
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 兵庫県神戸市
• [Presentation] IL-15は免疫応答細胞のアポトーシスを抑制し、高齢マウス敗血症の生命予後を改善する (2012)
  • Author(s): 井上 茂亮
  • Organizer: 第19回外科侵襲とサイトカイン研究会
  • Place of Presentation: 兵庫県神戸市
• [Presentation] 高齢者敗血症における末梢血単核球の免疫機能解析 (2011)
  • Author(s): 井上 茂亮
  • Organizer: 第39回日本集中治療医学会学術集会
  • Place of Presentation: 千葉県千葉市幕張メッセ
• [Presentation] Klothoマウス敗血症モデルにおける免疫機能解析 (2011)
  • Author(s): 井上 茂亮
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉県千葉市幕張メッセ
• [Remarks]
  • URL: http://www.u-tokai.ac.jp/tuiist/tt/announcement_inoue.html