Immunoanalysis of severe septic patients in the elderly and therapeutic potential of IL-15
| Project/Area Number |
23792088
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Tokai University |
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Principal Investigator |
INOUE Shigeaki 東海大学, 創造科学技術研究機構, 講師 (30582209)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 高齢者 / 敗血症 / 免疫 / IL-15 / 老化 / T細胞 |
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| Research Abstract |
Reduction of immunocompetent T cells followed byprolonged lymphopenia may be associated with poor prognosis in elderly septic patients.IL-15 reactivates exhausted T cells and improves survival of sepsis in aged mice.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Reduction of immunocompetent T cells followed by prolonged lymphopenia in severe sepsis in the elderly2013
Author(s)
Inoue S, Suzuki-Utsunomiya K, Okada Y, Iida Y, Taira T, Miura N, Tsuji T, Yamagiwa T, Morita S, Chiba T, Sato T, Inokuchi S
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Journal Title
Crit Care Med
Volume: 41
Pages: 810-819
Related Report
Peer Reviewed
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[Presentation]2012
Author(s)
Inoue S, Suzuki-Utsumoniya K, Komori Y, Sato T, Inokuchi S
Organizer
日本外科代謝栄養学会第49回学術集会日韓合同シンポジウム講演
Place of Presentation
千葉
Year and Date
2012-07-06
Related Report
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