| Project/Area Number |
23792090
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Emergency medicine
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
ABUKAWA Yukako 東京女子医科大学, 医学部, 助教 (00318148)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | 敗血症 / アラキドン酸カスケード / ＮＦｋＢデコイ / NFkＢ / ＮＦｋＢ / ロイコトリエン |
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| Research Abstract |
We established the colon ascendens stent puncture model in mice. An NFkB decoy was used for this treatment. The suvival rate improved from 73% to 100% in the pre-treatment group.The concentration of leucotoriene in the BALF decreased from 4.2ng/ml to 1.3mg/ml in the pre-treatment group. A significant different was thus observed between the CASP group and pre-treatment group. We concluded that the inflammation in the abdominal cavity had been suppressed by intra-peritoneal administration of NFkB decoy. Thereafter inflammation of the lungs had been suppressed. It may prevented the onset of sepsis-related shock.
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