| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
The aim of this study was to elucidate the pathophysiology of sepsis-associated organ dysfunction involving the Ang/Tie2 signaling pathway and to establish a new therapeutic strategy for treating critical illnesses, such as sepsis, severe trauma and post-cardiac arrest syndrome. I examined the relationship between organ dysfunction associated with critical illness and angiogenic factors, including VEGF, Ang and their receptors and found that Ang2 plays a pivotal role in the development of organ dysfunction due to coagulofibrinolytic abnormalities. The findings of this study have been presented at six domestic and four international conferences and have also been published by four peerreview articles.
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