The novel study model of cleft lip established by the interaction between genetic and environmental factors in mice

Research Project

Project/Area Number	23792098
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Morphological basic dentistry
Research Institution	Niigata University
Principal Investigator	NAKATOMI Mitsushiro 新潟大学, 医歯学系, 助教 (10571771)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	口唇裂 / 口蓋裂 / 先天異常 / 遺伝要因 / 環境要因 / マウス / 顔面発生 / Msx1 / 顎顔面形成
Research Abstract	As a result of keeping a pregnant mouse carrying the gene mutation of Msx1 under low oxygen environment for a certain period, mutant embryos exhibited the statistically higher frequency of cleft lip than wild-type embryos. Our results clearly demonstrated a concrete example of gene-environmental multifactorial threshold model, which has been theoretically advocated to explain a cause behind congenital anomalies. Our newly established experimental system would be of value to reveal the mechanisms ofcleft lip and palate in the future.