The novel study model of cleft lip established by the interaction between genetic and environmental factors in mice
| Project/Area Number |
23792098
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口唇裂 / 口蓋裂 / 先天異常 / 遺伝要因 / 環境要因 / マウス / 顔面発生 / Msx1 / 顎顔面形成 |
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| Research Abstract |
As a result of keeping a pregnant mouse carrying the gene mutation of Msx1 under low oxygen environment for a certain period, mutant embryos exhibited the statistically higher frequency of cleft lip than wild-type embryos. Our results clearly demonstrated a concrete example of gene-environmental multifactorial threshold model, which has been theoretically advocated to explain a cause behind congenital anomalies. Our newly established experimental system would be of value to reveal the mechanisms ofcleft lip and palate in the future.
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Report
(3 results)
Research Products
(2 results)
