Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Research Abstract |
As a result of keeping a pregnant mouse carrying the gene mutation of Msx1 under low oxygen environment for a certain period, mutant embryos exhibited the statistically higher frequency of cleft lip than wild-type embryos. Our results clearly demonstrated a concrete example of gene-environmental multifactorial threshold model, which has been theoretically advocated to explain a cause behind congenital anomalies. Our newly established experimental system would be of value to reveal the mechanisms ofcleft lip and palate in the future.
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