Apoptotic cell engulfment by cancer cells
Project/Area Number |
23792099
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Morphological basic dentistry
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Research Institution | Niigata University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 癌 / 病理学 / アポトーシス / 細胞・組織 / 貪食 / 口腔癌 / MFG-E8 |
Research Abstract |
Apoptotic oral squamous cell carcinoma (SCC) cells are engulfed not only by macrophages but also by neighboring SCC cells, which could be a potential anti-cancer avenue. Since apoptotic SCC cells were immunohistochemically positive for milk fat globule-epidermal growth factor-factor 8 (MFG-E8), one of the phagocytosis regulating molecules, apoptotic SCC cells were suggested to be removed by the MFG-E8-related phagocytotic pathways. In addition, MFG-E8 was simultaneously expressed in SCC cells forming small foci at the invading front, and its expression levels in SCC cells in culture were correlated with cell growth, anti-apoptotic activity and invasion. The results indicated that the apoptotic cell clearance via MFG-E8 produced by cancer cells enhances aggressiveness of cancer cell behaviors.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Emergence of keratin 17 vs. loss of keratin 13 : Their reciprocal immunohistochemical profiles in oral carcinoma in situ2011
Author(s)
Mikami T, Cheng J, Maruyama S, Kobayashi T, Funayama A, Yamazaki M, Adeola HA, Wu L, Shingaki S, Saito C, Saku T.
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Journal Title
Oral Oncology
Volume: 47(6)
Issue: 6
Pages: 497-503
DOI
Related Report
Peer Reviewed
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[Journal Article] Differential expression of perlecan receptors,α-dystroglycan and integrinβ1, before and after invasion of oral squamous cell carcinoma2011
Author(s)
Ahsan MS, Yamazaki M, Maruyama S, Kobayashi T, Ida-Yonemochi H, Hasegawa M, Adeola HA, Cheng J, Saku T.
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Journal Title
Journal of Oral
Volume: 40(7)
Issue: 7
Pages: 552-559
DOI
Related Report
Peer Reviewed
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[Presentation] 下顎腫瘍2011
Author(s)
山崎学,丸山智,程〓,藤田一,高木律男,林孝文,朔敬
Organizer
第22回日本臨床口腔病理学会総会・学術大会・第5回アジア口腔病理学会
Place of Presentation
福岡市
Related Report
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