| Project/Area Number |
23792099
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Morphological basic dentistry
|
|---|
| Research Institution | Niigata University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 癌 / 病理学 / アポトーシス / 細胞・組織 / 貪食 / 口腔癌 / MFG-E8 |
|---|
| Research Abstract |
Apoptotic oral squamous cell carcinoma (SCC) cells are engulfed not only by macrophages but also by neighboring SCC cells, which could be a potential anti-cancer avenue. Since apoptotic SCC cells were immunohistochemically positive for milk fat globule-epidermal growth factor-factor 8 (MFG-E8), one of the phagocytosis regulating molecules, apoptotic SCC cells were suggested to be removed by the MFG-E8-related phagocytotic pathways. In addition, MFG-E8 was simultaneously expressed in SCC cells forming small foci at the invading front, and its expression levels in SCC cells in culture were correlated with cell growth, anti-apoptotic activity and invasion. The results indicated that the apoptotic cell clearance via MFG-E8 produced by cancer cells enhances aggressiveness of cancer cell behaviors.
|
