Mechanisms of extra-molar development by Bcl11b mutation

• Project/Area Number: 23792100
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Niigata University
• Principal Investigator: KATSURAGI Yoshinori 新潟大学, 医歯学系, 助教 (60401759)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 口腔解剖学(含組織学・発生学) / Bcl11b / 歯胚形成 / ENU変異体

Research Abstract

We have showed that Bcl11b mice exhibited extra-molarsand hypoplastic maxillary incisors. In incisors of this mutant, hypoplasia of laCL whichcontains stem cells of ameloblast lineage, impaired proliferation of TA cells, and reducednumber of LRC were observed. Our data suggest that Bcl11b is not directly related to theFGF and Shh signaling but is intrinsic to ameloblast progenitors and possibly stem cells.

Research Products

• [Journal Article] Bcl11b transcription factor plays a role in the maintenance of the ameloblast-progenitors in mouse adult maxillary incisors. (2013)
  • Author(s): Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Obata M, Mishima Y, Sakuraba Y, Gondo Y, Kodama Y, Nishikawa A, Takagi R, Ohshima H, Kominami R.
  • Journal Title: Mechanism and Development Volume: 130 Issue: 9-10 Pages: 482-492
  • DOI: 10.1016/j.mod.2013.05.002
  • Peer Reviewed
• [Journal Article] Cell of origin in radiation-induced premalignant thymocytes in mice conditionally losing one Bcl11b allele. (2013)
  • Author(s): Go R, Hirose S, Katsuragi Y, Obata M, Abe M, Mishima Y, Sakimura K, Kominami R.
  • Journal Title: Cancer Science Volume: 104 Issue: 8 Pages: 1009-1016
  • DOI: 10.1111/cas.12193
  • Peer Reviewed
• [Journal Article] Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis (2012)
  • Author(s): R. Go, K. Takizawa, S. Hirose, Y. Katsuragi,Y. Aoyagi, S, Y. Mishima and R. Kominami
  • Journal Title: Leukemia Research Volume: 36 Issue: 8 Pages: 1035-1040
  • DOI: 10.1016/j.leukres.2012.04.028
  • Peer Reviewed
• [Presentation] Bcl11b transcription factor plays a role in the homeostasis of the ameloblast-progenitors in mouse adult maxillary incisors (2012)
  • Author(s): Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Mishima Y, Obata M, Sakuraba Y, Gondo Y, Takagi R, Oshima H, Kominami R.
  • Organizer: 第35回日本分子生物学会
  • Place of Presentation: 福岡市
  • Year and Date: 2012-12-12
• [Presentation] 木南凌放射線照射後の腸上皮におけるBcl11bの働き (2012)
  • Author(s): 葛城美徳、坂牧僚、小幡美貴、三嶋行雄、大塚健介
  • Organizer: 第55回日本放射線影響学会
  • Place of Presentation: 仙台市
  • Year and Date: 2012-09-07
• [Presentation] Bcl11b transcription factor controls the formation and maintenance of the ameloblast-lineage cells in mouse adult maxillary incisor (2011)
  • Author(s): Katsuragi Y, Anraku J, Nakatomi M, Ida-Yonemochi H, Mishima Y, Sakuraba Y, Gondo Y, Takagi R, Oshima H, Kominami R.
  • Organizer: 第34回日本分子生物学会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-12-13
• [Presentation] 木南凌Bcl11bの片アリル消失はγ線照射後のマウス小腸上皮幹細胞の増殖を促進する (2011)
  • Author(s): 葛城美徳、坂牧僚、小幡美貴、三嶋行雄
  • Organizer: 第54回日本放射線影響学会
  • Place of Presentation: 神戸市
  • Year and Date: 2011-11-18
• [Presentation] Loss of a Bcl11b allele promotes proliferation of stem cells in the mouse small intestine after γ-irradiation (2011)
  • Author(s): Katsuragi Y, Sakamaki A, Obata M, Mishima Y, Kominami R.
  • Organizer: ICRR(国際放射線研究連合会議)
  • Place of Presentation: ワルシャワ(ポーランド)
  • Year and Date: 2011-08-31
• [Presentation] 木南凌Bcl11bはエナメル芽細胞譜の形成と維持に関与する (2011)
  • Author(s): 葛城美徳、安楽純子、中富満城、依田浩子、三嶋行雄、桜庭喜行、権藤洋一、高木律男、大島勇人
  • Organizer: モロシヌス研究会
  • Place of Presentation: ホテルベルナティオ(新潟県十日町)
  • Year and Date: 2011-07-08
• [Presentation] 放射線照射後の腸上皮におけるBcl11bの働き
  • Author(s): 葛城美徳
  • Organizer: 日本放射線影響学会
  • Place of Presentation: 東北大学（仙台市）
• [Presentation] Bcl11b transcription factor plays a role in the homeostasis of the ameloblast-progenitors in mouse adult maxillary incisors
  • Author(s): 葛城美徳
  • Organizer: 日本分子生物学会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡市）
• [Presentation] Bcl11b はエナメル芽細胞系譜の形成と維持に関与する
  • Author(s): 葛城美徳
  • Organizer: モロシヌス研究会
  • Place of Presentation: ホテルベルナティオ（新潟県）
• [Presentation] Loss of a Bcl11b allele promotes proliferation of stem cells in the mouse small intestine after γ-irradiation
  • Author(s): 葛城美徳
  • Organizer: ICRR（国際放射線研究連合会議）
  • Place of Presentation: ワルシャワ（ポーランド）
• [Presentation] Bcl11bの片アリル欠損はγ線照射後のマウス小腸上皮幹細胞の増殖を促進する
  • Author(s): 葛城美徳
  • Organizer: 放射線影響学会
  • Place of Presentation: 神戸商工会議所会館 （兵庫県）
• [Presentation] Bcl11b transcription factor controls the formation and maintenance of ameloblast-lineage cells in mouse adult maxillary incisor
  • Author(s): 葛城美徳
  • Organizer: 日本分子生物学会
  • Place of Presentation: パシフィコ横浜（神奈川県）