Analysis of the premature birth-induced mechanism by the periodontal disease bacteria - cytomegalovirus superinfection model
| Project/Area Number |
23792102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
INABA Hiroaki 大阪大学, 歯学研究科(研究院), 助教 (70359850)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | P. gingivalis / 早産 / シグナル伝達 / アポトーシス / 細胞周期 / 低体重児出生 / 歯周病 / 全身疾患 / サイトメガロウイルス / トロホブラスト細胞 / DNA damage |
|---|
| Research Abstract |
P. gingivalis activates ERK1/2-Ets1 and the cellular DNA damage signaling pathways that act through an ATR/Chk2/p53-dependent pathway to cause G1 arrest and apoptosis in human trophoblast cells. Furthermore, P. gingivalis gingipain proteases degrade MDM2, which is the p53 degradation-related protein, thus contributing to p53 accumulation, G1 phase cell cycle arrest and apoptosis.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Distribution and molecular characterization of Porphyromonas gulae carrying a new fimA genotype2012
Author(s)
Yamasaki Y, Nomura R, Nakano K, Inaba H, Kuboniwa M, Hirai N, Shirai M, Kato Y, Murakami M, Naka S, Iwai S, Matsumoto-Nakano M, Ooshima T, Amano A, Asai F
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Journal Title
Veterinary Microbiology
Volume: 161(1)
Issue: 1-2
Pages: 196-205
DOI
Related Report
Peer Reviewed
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[Journal Article] Characterization of aortic aneurysms in cardiovascular disease patients harboring Porphyromonas gingivalis2011
Author(s)
Nakano K, Wada K, Nomura R, Nemoto H, Inaba H, Kojima A, Naka S, Hokamura K, Mukai T, Nakajima A, Umemura K, Kamisaki Y, Yoshioka H, Taniguchi K, Amano A, Ooshima T
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Journal Title
Oral Diseases
Volume: 17(4)
Issue: 4
Pages: 370-378
DOI
Related Report
Peer Reviewed
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