| Project/Area Number |
23792102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
INABA Hiroaki 大阪大学, 歯学研究科(研究院), 助教 (70359850)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | P. gingivalis / 早産 / シグナル伝達 / アポトーシス / 細胞周期 / 低体重児出生 / 歯周病 / 全身疾患 / サイトメガロウイルス / トロホブラスト細胞 / DNA damage |
|---|
| Research Abstract |
P. gingivalis activates ERK1/2-Ets1 and the cellular DNA damage signaling pathways that act through an ATR/Chk2/p53-dependent pathway to cause G1 arrest and apoptosis in human trophoblast cells. Furthermore, P. gingivalis gingipain proteases degrade MDM2, which is the p53 degradation-related protein, thus contributing to p53 accumulation, G1 phase cell cycle arrest and apoptosis.
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