Study on the mechanism of F-spondin/LDL receptor family for hard tissue destruction

• Project/Area Number: 23792103
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Hiroshima University
• Principal Investigator: OKA HIROKO 広島大学, 医歯薬保健学研究院(歯), 特任助教 (60452588)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 硬組織破壊 / 歯周組織 / F-spondin / LDL受容体ファミリー / 受容体

Research Abstract

We demonstrated that F-spondin downregulated migration and differentiation of precursor osteoclasts partially via one of LDL receptor family, Lrp8. Moreover, our data suggested that LDL receptor family members on precursor osteoclasts, themselves regulated migration and differentiation of precursor osteoclasts independently of F-spondin.
F-spondin-expressed cells maintained osteoclastogenesis by secretory F-spondin and other factors. Also, F-spondin expression on cells affected the expression level of LDL receptor family members on it.

Research Products

• [Presentation] セメント芽細胞が発現するF-spondinの抗炎症作用に関する検討 (2013)
  • Author(s): 北川雅恵,宮内睦美,岡広子,外丸祐介,高田隆
  • Organizer: 第55回歯科基礎医学会学術大会
  • Place of Presentation: 岡山コンベンションセンター(岡山)
  • Year and Date: 2013-09-22
• [Presentation] F-spondinは歯周組織の硬組織破壊を抑制する (2013)
  • Author(s): 岡広子,北川雅恵,高田隆
  • Organizer: 第55回歯科基礎医学会学術大会
  • Place of Presentation: 岡山コンベンションセンター(岡山)
  • Year and Date: 2013-09-21
• [Presentation] F-spondinは歯周組織の硬組織破壊を抑制する (2013)
  • Author(s): 岡広子，北川雅恵，高田隆
  • Organizer: 第55回歯科基礎医学会学術大会．
  • Place of Presentation: 岡山
• [Presentation] F-spondin Protects the Root Surface from Resorption (2012)
  • Author(s): Hiroko Oka, Masae Kitagawa, Takashi Takata
  • Organizer: The 60th Annual Meeting of Japanese Association for Dental Research
  • Place of Presentation: 新潟コンベンションセンター(新潟)
  • Year and Date: 2012-12-15
• [Presentation] F-spondin Protects the Root Surface from Resorption. (2012)
  • Author(s): Hiroko Oka, Masae Kitagawa, Takashi Takata
  • Organizer: 第60回国際歯科研究学会
  • Place of Presentation: 新潟