Project/Area Number |
23792105
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Morphological basic dentistry
|
Research Institution | Hiroshima University |
Principal Investigator |
MINAMIZAKI Tomoko 広島大学, 大学院・医歯薬保健学研究院, 助教 (30452593)
|
Research Collaborator |
YOSHIKO Yuji 広島大学, 大学院・医歯薬保健学研究院, 教授 (20263709)
YOSHIOKA Hirotaka 広島大学, 大学院・医歯薬保健学研究院, 助教 (50523411)
KOZAI Katsuyuki 広島大学, 大学院・医歯薬保健学研究院, 教授 (10178212)
|
Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 細胞・組織 / 骨代謝 / リン代謝 / PTH / FGF23 / 骨芽細胞 |
Research Abstract |
PTH increased the promoter activity of Fgf23 in rat calvaria-derived osteoblast cell cultures, however, there was no significant change in the levels of Fgf23mRNA expression and production. In combination with dihydroxyvitamin D3(1,25D), on the other hand, PTH decreased 1,25D-induced Fgf23mRNA expression and production. One of the reasons for this effect is that the expression of vitamin D receptor and type III sodium-dependent phosphate transporter (Pit1) was suppressed by PTH. Further, PTH promoted MKP1 phosphorylation via PKA pathway, and thereby attenuated the signal FGF23 signaling.
|