| Project/Area Number |
23792108
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Cbfb / Runx2 / 骨芽細胞 / 軟骨細胞 / 骨形成 / コンディショナルノックアイトマウス / Dermo1 / コンディショナルノックアウトマウス / RUNXファミリー / 骨格の形成 / 歯の形成 / ノックアウトマウス / ノックインマウス |
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| Research Abstract |
Cbfb is a cotranscription factor of Runx proteins. It forms a heterodimer with Runx family proteins and binds to DNA. To elucidate the function of Cbfb in skeletal development, we generated conditional knockout mice, in which Cbfb was deleted in mesenchymal cells in whole body. In Cbfb conditional knockout mice, bone formation and chondrocyte differentiation were retarded, indicating that Cbfb plays an important role in skeletal development.
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