A study to develop a novel therapeutic/ preventive strategy for oral bacterial infectious diseases based on the obstruction of lipoprotein modification enzymes
| Project/Area Number |
23792113
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | lipoprotein / prolipoprotein diacylglyceryl transferase / Streptococcus mutans / signal peptidase / Streptococcus gordonii / 浸透圧抵抗性 / 貪食抵抗性 / リポ蛋白質 / 耐酸性 / 二成分制御系 |
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| Research Abstract |
We have been engaged in the work regarding surface lipoprotein on cariogenic bacterium, Streptococcus mutans. Until now, we have identified and functional analyzed lipoproteins related to sugar and amino acid uptake. Moreover, these lipoproteins have been clarified to be modified by lipoprotein modification enzymes, prolipoprotein diacylglyceryl transferase (Lgt) and lipoprotein-specific signal peptidase II (LspA), which is very important for the pysiological function of the lipoproteins. In this study, we identified that lipoprotein OpcC was involved in the acid tolerance which is one of cariogenic properties of S. mutans and demonstrated that the lipoprotein OpcC was under the control of Lgt and LspA in the localization and physiological function. Accumulated evidence and this finding strongly suggest that lipoproteins are definitely related to the pathogenic properties of S. mutans. Furthermore, lipoprotein modification enzymes should be attractive targets to develop a new strategy for prevention and therapeutic against dental caries.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Toll-like receptor 2-mediated modulation of growth and functions of regulatory T cells by oralstreptococci2013
Author(s)
Saeki, Ayumi; Segawa, Taku; Abe, Tsugumi; Sugiyama, Masahiro; Arimoto, Takafumi; Hara, Hiroshi; Hasebe, Akira; Ohtani, Makoto; Tanizume, Naoho; Ohuchi, Manabu; Kataoka, Hideo; Kawanami, Masamitsu; Yokoyama, Atsuro; Ken-ichiro
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Journal Title
Molecular Oral Microbiology
Volume: (In press)
Related Report
Peer Reviewed
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[Journal Article] Toll-like receptor 2-mediated modulation of growth and functions of regulatory T cells by oral streptococci2013
Author(s)
A. Saeki, T. Segawa, T. Abe, M. Sugiyama, T. Arimoto, H. Hara, A.Hasebe, M. Ohtani, N. Tanizume, M. Ohuchi, H. Kataoka, M. Kawanami, A. Yokoyama and K. Shibata.
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Journal Title
Mol Oral Microbiol
Volume: 未定
Issue: 4
Pages: 1-14
DOI
Related Report
Peer Reviewed
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