Functional analysis of HPIP in invasion of oral squamous cell carcinoma

• Project/Area Number: 23792115
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: Showa University
• Principal Investigator: YAMAMOTO Gou 昭和大学, 歯学部, 講師 (80384189)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 口腔扁平上皮癌 / 浸潤 / LC/MS/MS / HPIP(PBXIP1) / 口腔扁平上皮がん / HPIP（PBXIP1） / HPIPタンパク質

Research Abstract

Oral squamous cell carcinoma indicates various phenotypes; obvious invasion, early invasion and no invasive carcinoma. In pathological diagnosis, we often face a case with difficult judgment of invasion of cancer. We identified HPIP as a marker of cancer invasion by new LC/MS/MS method. Our study suggest that HPIP was a useful marker for evaluate of cancer invasion.

Research Products

• [Journal Article] Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma. (2013)
  • Author(s): Hayashi S, Tanaka J, Okada S, Isobe T, Yamamoto G, Yasuhara R, Irie T, Akiyama C, Kohno Y, Tachikawa T, Mishima K.
  • Journal Title: Exp Cell Res Volume: 319 Issue: 8 Pages: 1220-1228
  • DOI: 10.1016/j.yexcr.2013.03.004
  • Peer Reviewed
• [Journal Article] Expression of myelin and lymphocyte protein (MAL) in oral carcinogenesis. (2012)
  • Author(s): Pal SK, Noguchi S, Yamamoto G, Yamada A, Isobe T, Hayashi S, Tanaka J, Tanaka Y, Kamijo R, Yamane GY, Tachikawa T
  • Journal Title: Med Mol Morphol Volume: 45 Issue: 4 Pages: 222-228
  • DOI: 10.1007/s00795-011-0563-2
  • NAID: 10031137147
  • Peer Reviewed
• [Presentation] 乳癌骨転移誘導因子の検索とその機能解析 (2012)
  • Author(s): 安原理佳、沢田晃暢、鈴木研也、中村清吾、山本 剛、入江太朗、美島健二
  • Organizer: 第101回日本病理学会
  • Place of Presentation: 東京
• [Presentation] 扁平上皮癌細胞株における癌幹細胞の特性 (2011)
  • Author(s): 林 茂雄、磯辺友秀、立川哲彦、田中準一、岡田誠二、外薗知恵、山本 剛、入江太朗、美島健二
  • Organizer: 第31回昭和歯学会
  • Place of Presentation: 東京
• [Presentation] 口腔扁平上皮癌細胞株のスフェロイド培養法における、癌幹細胞様細胞の特性について (2011)
  • Author(s): 田中準一、磯辺友秀、立川哲彦、林 茂雄、岡田誠二、外薗知恵、山本 剛、入江太朗、美島健二
  • Organizer: 第31回昭和歯学会
  • Place of Presentation: 東京
• [Presentation] 乳癌骨転移因子の探索と機能解析 (2011)
  • Author(s): 安原理佳, 角田ゆう子, 鈴木研也, 沢田晃暢, 中村清吾, 佐々木晶子, 山本 剛, 入江太朗, 立川哲彦
  • Organizer: 第19回日本乳癌学会
  • Place of Presentation: 仙台
• [Presentation] 乳癌骨転移におけるb-Cateninシグナルの役割 (2011)
  • Author(s): 安原理佳, 佐々木晶子, 山本剛, 入江太朗, 角田ゆう子, 鈴木研也, 沢田晃暢, 中村清吾,立川哲彦
  • Organizer: 第100回日本病理学会
  • Place of Presentation: 神奈川