The neural mechanisms involved in the perception of burning taste of capsaicin and subsequent autonomic responses.

• Project/Area Number: 23792123
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Functional basic dentistry
• Research Institution: Osaka University
• Principal Investigator: SATO Hajime 大阪大学, 歯学研究科(研究院), 助教 (10432452)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 口腔生理学 / 神経生理学 / 大脳皮質 / 味覚 / TRPV1 / 辛味 / fMRI / 島皮質 / 同期化 / カプサイシン / 国際情報交換 / 韓国 / 国際情報交流

Research Abstract

Voltage-sensitive dye imaging demonstrated that TRPV1 activation in Gustatory insular cortex(Gu-I) can alter an optical response with a monophasic and columnar temporospatial pattern evoked within Gu-I into an oscillatory one extending over Gu-I and Autonomic insular cortex(Au-I). An fMRI study in human subjects also demonstrated that the tasting of capsaicin cause excitation in Gu-I and Au-I. These results suggest that Gu-I processes the sensory information of hot and spicy taste of capsaicin.

Research Products

• [Journal Article] Enhanced desensitization followed by unusual resensitization in GABAA receptors in phospholipase C-related catalytically inactive protein-1/2 double-knockout mice (2014)
  • Author(s): Toyoda, H., Saito, M., Sato, H., Tanaka, T., Ogawa, T., Yatani, H., Kawano, T., Kanematsu, T., Hirata, M. & Kang, Y.
  • Journal Title: Pflugers Archiv - European Journal of Physiology Volume: In press
  • Peer Reviewed
• [Journal Article] Teeth clenching reduces arm abduction force (2014)
  • Author(s): Sato, H., Kawano, T., Saito, M., Toyoda, H., Maeda, Y., Turker, K.S. & Kang, Y.
  • Journal Title: Experimental Brain Research Volume: In press
  • Peer Reviewed
• [Journal Article] GABAB receptor-mediated presynaptic inhibition reverses inter-columnar covariability of synaptic actions by intracortical axons in the rat barrel cortex (2013)
  • Author(s): Sato H, Toyoda H, Saito M, Kobayashi M, Althof D, Kulik A, Kang Y
  • Journal Title: The European Journal of Neuroscience Volume: 37 Issue: 2 Pages: 190-202
  • DOI: 10.1111/ejn.12041
  • Peer Reviewed
• [Journal Article] A mathematical model of negative covariability of inter-columnar excitatory synaptic actions caused by presynaptic inhibition (2013)
  • Author(s): Saito M, Tanaka T, Sato H, Toyoda H, Aoyagi T, Kang Y
  • Journal Title: The European Journal of euroscience Volume: 38 Issue: 7 Pages: 2999-3007
  • DOI: 10.1111/ejn.12299
  • Peer Reviewed
• [Journal Article] Capsaicin induces Theta-band synchronization between gustatory and autonomic insular cortices (2012)
  • Author(s): Saito, M., Toyoda, H., Kawakami, S., Sato, H., Bae, YC. & Kang, Y.
  • Journal Title: The Journal of Neuroscience Volume: 32(39) Pages: 13470-13487
  • Peer Reviewed
• [Journal Article] 噛みしめ運動における咬筋運動ニューロン序列動員の階層性制御機構 (2011)
  • Author(s): 姜英夫,斎藤充,豊田博紀,佐藤元
  • Journal Title: 脳21 Volume: 14(4) Pages: 385-391
• [Journal Article] 噛みしめ運動における咬筋運動ニューロン序列動員の階層性制御機構 (2011)
  • Author(s): 姜英男、斎藤充、豊田博紀、佐藤元
  • Journal Title: 脳21 Volume: vol. 14 No. 4 Pages: 385-391
• [Journal Article] Enhanced desensitization followed by unusual resensitization in GABA_A receptors in phospholipase C-related catalytically inactive protein-1/2 double-knockout mice
  • Author(s): Toyoda, H., Saito, M., Sato, H., Tanaka, T., Ogawa, T., Yatani, H., Kawano, T., Kanematsu, T., Hirata, M. & Kang, Y.
  • Journal Title: Pflugers Archiv - European Journal of Physiology Volume: (In press)
  • Peer Reviewed
• [Journal Article] Teeth clenching reduces arm abduction force
  • Author(s): Sato, H., Kawano, T., Saito, M., Toyoda, H., Maeda, Y., Turker, K.S. & Kang, Y.
  • Journal Title: Experimental Brain Research Volume: (In press)
  • Peer Reviewed
• [Presentation] 学的膜電位測定によって観察されたラットバレル野における周期的同期化 (2013)
  • Author(s): 佐藤元
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 岡山コンベンションセンター(岡山県)
• [Presentation] 光学的膜電位測定によって観察されたラットバレル野第2/3層神経活動のGABAB受容体依存的ペアドパルス抑制 (2013)
  • Author(s): 佐藤元
  • Organizer: Neuro 2013
  • Place of Presentation: 国立京都国際会館(京都府)
• [Presentation] 光学的膜電位測定によって観察されたラットバレル野における周期的同期化 (2013)
  • Author(s): 佐藤元
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 岡山コンベンションセンター
• [Presentation] 光学的膜電位測定によって観察されたラットバレル野第2/3層神経活動のGABAB受容体依存的ペアドパルス抑制 (2013)
  • Author(s): 佐藤元
  • Organizer: Neuro2013
  • Place of Presentation: 国立京都国際会館
• [Presentation] 閉口筋運動ニューロンの序列動員とcGMPによるその修飾 (2011)
  • Author(s): 佐藤元
  • Organizer: 歯科基礎医学会
  • Place of Presentation: 長良川国際会議場(岐阜県)
  • Year and Date: 2011-10-01
• [Presentation] 閉口筋運動ニューロンの序列動員とcGMPによるその修飾 (2011)
  • Author(s): 佐藤 元、深津 雄己、 豊田 博紀、 齋藤 充、姜 英男
  • Organizer: 第５３回 歯科基礎医学会学術大会
  • Place of Presentation: 長良川国際会議場 (岐阜県）
• [Remarks] 口腔生理学教室ホームページ
  • URL: http://web.dent.osaka-u.ac.jp/~phys/
• [Remarks] 「辛味」認知が大脳島皮質の自律機能を賦活化するメカニズム発見
  • URL: http://www.osaka-u.ac.jp/ja/news/ResearchRelease/2012/10/20121017_1
• [Remarks]
  • URL: http://web.dent.osaka-u.ac.jp/~phys/