Functional coupling of sensory reception and dentin formation following external stimuli in odontoblasts.
| Project/Area Number |
23792132
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
TSUMURA Maki 東京歯科大学, 生理学講座, 助手 (90582346)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 口腔生理学 / 象牙芽細胞 / TRPチャネル |
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| Research Abstract |
Functional TRPV1- Na+-Ca2+exchager coupling mediates Ca2+extrusion to drive reactional dentinogenesis and maintain [Ca2+]ihomeostasis. This study suggests that two separate dental pulp functions, that in protective dentin formation and that in sensory reception, are simultaneously driven by TRPV1, TRPM8, TRPA1 activation following stimuli applied external to odontoblasts.
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] Hypotonic-induced stretching of plasma membrane activates TRPV channels and sodium-calcium exchangers in mouse odontoblasts2013
Author(s)
Masaki Sato, Ubaidus Sobhan, Maki Tsumura, Hidetaka Kuroda, Manabu Soya, Aya Masamura, Akihiro Nishiyama, Akira Katakura, Tatsuya Ichinohe, Masakazu Tazaki, Yoshiyuki Shibukawa
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Journal Title
Journal of endodontics
Volume: 未定
Issue: 6
Pages: 779-787
DOI
Related Report
Peer Reviewed
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