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Functional coupling of sensory reception and dentin formation following external stimuli in odontoblasts.

Research Project

Project/Area Number 23792132
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionTokyo Dental College

Principal Investigator

TSUMURA Maki  東京歯科大学, 生理学講座, 助手 (90582346)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords口腔生理学 / 象牙芽細胞 / TRPチャネル
Research Abstract

Functional TRPV1- Na+-Ca2+exchager coupling mediates Ca2+extrusion to drive reactional dentinogenesis and maintain [Ca2+]ihomeostasis. This study suggests that two separate dental pulp functions, that in protective dentin formation and that in sensory reception, are simultaneously driven by TRPV1, TRPM8, TRPA1 activation following stimuli applied external to odontoblasts.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (39 results)

All 2013 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (32 results)

  • [Journal Article] Hypotonic-induced stretching of plasma membrane activates TRPV channels and sodium-calcium exchangers in mouse odontoblasts2013

    • Author(s)
      Masaki Sato, Ubaidus Sobhan, Maki Tsumura, Hidetaka Kuroda, Manabu Soya, Akihiro Nishiyama, Akira Katakura,Tatsuya Ichinohe, Masakazu Tazaki and Yoshiyuki Shibukawa.
    • Journal Title

      J Endod

      Volume: 39 Pages: 779-787

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 象牙芽細胞におけるtransient receptor potential melastatin subfamily member 8チャネルの発現の検索2013

    • Author(s)
      高橋史子
    • Journal Title

      医学と生物学

      Volume: 157(6) Pages: 985-990

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypotonic-induced stretching of plasma membrane activates TRPV channels and sodium-calcium exchangers in mouse odontoblasts2013

    • Author(s)
      Masaki Sato, Ubaidus Sobhan, Maki Tsumura, Hidetaka Kuroda, Manabu Soya, Aya Masamura, Akihiro Nishiyama, Akira Katakura, Tatsuya Ichinohe, Masakazu Tazaki, Yoshiyuki Shibukawa
    • Journal Title

      Journal of endodontics

      Volume: 未定 Issue: 6 Pages: 779-787

    • DOI

      10.1016/j.joen.2013.01.012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage-dependent sodium channels and calcium-activated potassium channels in human odontoblasts in vitro2012

    • Author(s)
      Ichikawa H, Kim H.J, Shuprisha A, Shikano T, Tsumura M, Shibukawa Y and Tazaki M.
    • Journal Title

      J Endod

      Volume: 38 Pages: 1355-1362

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts2012

    • Author(s)
      Tsumura M, Sobhan U, Muramatsu T, Sato M, Ichikawa H, Sahara Y, Tazaki M, Shibukawa Y.
    • Journal Title

      Cell Calcium.

      Volume: 52 Pages: 124-136

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bradykinin up-regulates voltage-dependent sodium channels in human odontoblast2012

    • Author(s)
      Masakazu Tazaki, Hideki Ichikawa, Maki Tsumura, Masaki Sato, Ubaidus Sobhan, Yoshiyuki Shibukawa
    • Journal Title

      医学と生物学

      Volume: 156 Pages: 404-409

    • NAID

      40019331706

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] TRPV1-mediated calcium signal couples with cannabinoid receptors and sodium-calcium exchangers in rat odontoblasts2012

    • Author(s)
      M Tsumura, U Sobhan, T Muramatsu, M Sato, H Ichikawa, Y Sahara, M Tazaki, Y Shibukawa
    • Journal Title

      Cell Calcium

      Volume: 52 Issue: 2 Pages: 124-136

    • DOI

      10.1016/j.ceca.2012.05.002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Expression of TRPM8 and TRPA1 channels in rat odontoblasts2013

    • Author(s)
      Masaki Sato
    • Organizer
      11th International Conference on Tooth Morphogenesis and Ditterentiation
    • Place of Presentation
      France
    • Related Report
      2012 Annual Research Report
  • [Presentation] Functional role of thermosensitive TRP channels in salivaly gland during salivary secretion2012

    • Author(s)
      Ubaidus Sobhan, Masaki Sato, Takashi Shinomiya, Migiwa Okubo, Maki Tsumura,Masao Yoshinari, Takashi Inoue, Masakazu Tazaki, Mitsuru Kwaguchi, Yoshiyuki Shibukawa.
    • Organizer
      第294回東京歯科大学学会
    • Place of Presentation
      千葉市
    • Year and Date
      2012-10-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 象牙芽細胞におけるグルタミン酸受容体の機能検索2012

    • Author(s)
      西山明宏、佐藤正樹、津村麻記、田崎雅和、片倉朗、澁川義幸
    • Organizer
      第294回東京歯科大学学会
    • Place of Presentation
      千葉市
    • Year and Date
      2012-10-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 象牙芽細胞における細胞膜伸展刺激受容と三叉神経節細胞共培養系における連絡機構2012

    • Author(s)
      佐藤正樹、津村麻記、黒田英孝、川口綾、Sobhan Ubaidus、西山明宏、吉成正雄、井上孝、田崎雅和、澁川義幸
    • Organizer
      第294回東京歯科大学学会
    • Place of Presentation
      千葉市
    • Year and Date
      2012-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] グアヤコールは象牙芽細胞の Ca2+チャネルに直接作用する2012

    • Author(s)
      〓田みゆき、津村麻記、佐藤正樹、Sobhan Ubaidus、山下秀一郎、田崎雅和、澁川義幸
    • Organizer
      第294回東京歯科大学学会
    • Place of Presentation
      千葉市
    • Year and Date
      2012-10-20
    • Related Report
      2012 Final Research Report
  • [Presentation] 象牙芽細胞における TRPM8 チャネルと TRPA1 チャネルの発現検索2012

    • Author(s)
      津村麻記、Sobhan Ubaidus、佐藤正樹、西山明宏、田崎雅和、澁川義幸
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      郡山市
    • Year and Date
      2012-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 唾液腺における TRP チャネル発現と分泌メカニズム2012

    • Author(s)
      Sobhan Ubaidus、佐藤正樹、四宮敬史、大久保みぎわ、津村麻記、田崎雅和、川口充
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      郡山市
    • Year and Date
      2012-09-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 象牙芽細胞における TRPV1 チャネル・CB1 受容体・Na+-Ca2+交換体の機能連関2012

    • Author(s)
      津村麻記、Sobhan Ubaidus、佐藤正樹、西山明宏、田崎雅和、澁川義幸
    • Organizer
      第6回トランスポーター研究会九州部会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス象牙芽細胞系細胞における細胞膜伸展刺激受容TRP channels と NCX の機能関連2012

    • Author(s)
      佐藤正樹、津村麻記、Sobhan Ubaidus、黒田英孝、田崎雅和、澁川義幸
    • Organizer
      第6回トランスポーター研究会九州部会
    • Place of Presentation
      福岡市
    • Year and Date
      2012-09-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 象牙芽細胞系細胞における機械刺激受容と三叉神経節細胞共培養系における伝達機構2012

    • Author(s)
      佐藤正樹、津村麻記、Sobhan Ubaidus、黒田英孝、征矢学、正村綾、田崎雅和、一戸達也、澁川義幸
    • Organizer
      第11回釧路ニューロサイエンスワークショップ
    • Place of Presentation
      釧路市
    • Year and Date
      2012-07-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Imunolocalization of potassium dependent (NCKX) andpotassium independent (NCX) Na+/Ca2+exchanger proteins in salivary glands2012

    • Author(s)
      Sobhan Ubaidus, Muramatsu Takashi,Tsumura Maki, Sato Masaki, Tazaki Masakazu, Shibukawa Yoshiyuki
    • Organizer
      第89回日本生理学会
    • Place of Presentation
      松本市
    • Year and Date
      2012-03-31
    • Related Report
      2012 Final Research Report
  • [Presentation] 象牙芽細胞におけるTRPM8チャネルとTRPA1チャネルの発現検索2012

    • Author(s)
      津村麻記
    • Organizer
      第54回歯科基礎医学会学術大会
    • Place of Presentation
      郡山市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 象牙芽細胞における TRPM8/TRPA1チャネルの発現の検索2011

    • Author(s)
      高橋史子、津村麻記、Sobhan Ubaidus、村松敬、佐藤正樹、市川秀樹、田崎雅和、澁川義幸
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜市
    • Year and Date
      2011-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] ユージノールは象牙芽細胞の TRPV1 チャネルに作用する2011

    • Author(s)
      田中らいら、佐藤正樹、津村麻記、Sobhan Ubaidus、市川秀樹、田崎雅和、澁川義幸
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜市
    • Year and Date
      2011-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 象牙芽細胞における TRPV1/TRPV2 チャネルを介した外的刺激受容と象牙質形成の機能連関2011

    • Author(s)
      津村麻記、Sobhan Ubaidus、佐藤正樹、村松敬、田崎雅和、澁川義幸
    • Organizer
      第31回日本歯科薬物療法学会
    • Place of Presentation
      千葉市
    • Year and Date
      2011-06-25
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス象牙芽細胞系細胞における浸透圧受容器 TRPV4 と Na+-Ca2+交換体の機能連関2011

    • Author(s)
      佐藤正樹、津村麻記、Ubaidus Sobhan、市川秀樹、村松敬、田崎雅和、澁川義幸
    • Organizer
      第31回日本歯科薬物療法学会
    • Place of Presentation
      千葉市
    • Year and Date
      2011-06-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Localization and the Role of TRPs in Salivary Gland.2011

    • Author(s)
      Ubaidus Sobhan、村松敬、佐藤正樹、津村麻記、田崎雅和、澁川義幸
    • Organizer
      第31回日本歯科薬物療法学会
    • Place of Presentation
      千葉市
    • Year and Date
      2011-06-25
    • Related Report
      2012 Final Research Report
  • [Presentation] Functional coupling between TRPV1, CB1 and NCXs in rat odontoblasts2011

    • Author(s)
      Tsumura M, Shibukawa Y, Muramatsu T, Sobhan U, Sato M, Ichikawa H, TazakiM
    • Organizer
      6thInternational Conference on Na+/Ca2+exchange 2011
    • Place of Presentation
      Ischia, Naples, Italy
    • Related Report
      2012 Final Research Report
  • [Presentation] Potassium dependent and independent Na+/Ca2+exchanger proteins is mainly expressed in myoepithelial cells/ductal cells of rat salivary glands2011

    • Author(s)
      Sobhan U, Muramatsu T, Sato M, Tsumura M, Tazaki M, Shibukawa Y.
    • Organizer
      6thInternational Conference on Na+/Ca2+exchange 2011
    • Place of Presentation
      Ischia, Naples, Italy
    • Related Report
      2012 Final Research Report
  • [Presentation] NCX expression in enamel/dentin-forming cells2011

    • Author(s)
      Shibukawa Y, Tsumura M, Sato M, Ubaidus S, Muramatsu T, Matsuda T, Baba A, Tazaki M.
    • Organizer
      6thInternational Conference on Na+/Ca2+exchange 2011
    • Place of Presentation
      Ischia, Naples, Italy
    • Related Report
      2012 Final Research Report
  • [Presentation] Activation of TRP channels by osmotic stimulation and Ca2+extrusion by Na+-Ca2+exchangers in mouse odontoblast lineage cells2011

    • Author(s)
      Sato M, Sobhan U, Tsumura M, Ichikawa H, Tazaki M, Muramatsu T, ShibukawaY.
    • Organizer
      6thInternational Conference on Na+/Ca2+exchange 2011
    • Place of Presentation
      Ischia, Naples, Italy
    • Related Report
      2012 Final Research Report
  • [Presentation] 象牙芽細胞におけるTRPV1チャネル・CB1受容体・Na+-Ca2+交換体の機能連関

    • Author(s)
      津村麻記
    • Organizer
      第6回トランスポーター研究会九州部会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Annual Research Report
  • [Presentation] 象牙芽細胞のTRPV1/TRPV2チャネルを介した外的刺激受容と象牙質形成の機能連関

    • Author(s)
      津村麻記、澁川義幸、Sobhan Ubaidus、佐藤正樹、田崎雅和
    • Organizer
      第31回日本歯科薬物療法学会
    • Place of Presentation
      千葉市
    • Related Report
      2011 Research-status Report
  • [Presentation] マウス象牙芽細胞系細胞における浸透圧受容器TRPV4とNa+-Ca2+交換体の機能連関

    • Author(s)
      佐藤正樹、津村麻記、Ubaidus Sobhan、市川秀樹、村松敬、田崎雅和、澁川義幸
    • Organizer
      第31回日本歯科薬物療法学会
    • Place of Presentation
      千葉市
    • Related Report
      2011 Research-status Report
  • [Presentation] Localization and the Role of TRPs in Salivary Gland

    • Author(s)
      Ubaidus Sobhan、村松敬、佐藤正樹、津村麻記、田崎雅和、澁川義幸
    • Organizer
      第31回日本歯科薬物療法学会
    • Place of Presentation
      千葉市
    • Related Report
      2011 Research-status Report
  • [Presentation] Functional coupling between TRPV1, CB1 and NCXs in rat odontoblasts

    • Author(s)
      Tsumura M, Shibukawa Y, Muramatsu T, Sobhan U, Sato M, Ichikawa H, Tazaki M
    • Organizer
      6th International Conference on Na+/Ca2+ Exchange 2011
    • Place of Presentation
      Naples, Italy
    • Related Report
      2011 Research-status Report
  • [Presentation] Potassium dependent and independent Na+/Ca2+ exchanger proteins is mainly expressed in myoepithelial cells/ductal cells of rat salivary glands

    • Author(s)
      Sobhan U, Muramatsu T, Sato M, Tsumura M, Tazaki M, Shibukawa Y
    • Organizer
      6th International Conference on Na+/Ca2+ Exchange 2011
    • Place of Presentation
      Naples, Italy
    • Related Report
      2011 Research-status Report
  • [Presentation] NCX expression in enamel/dentin-forming cells

    • Author(s)
      Shibukawa Y, Tsumura M, Sato M, Ubaidus S, Muramatsu T, Matsuda T, Baba A, Tazaki M
    • Organizer
      6th International Conference on Na+/Ca2+ Exchange 2011
    • Place of Presentation
      Naples, Italy
    • Related Report
      2011 Research-status Report
  • [Presentation] Activation of TRP channels by osmotic stimulation and Ca2+ extrusion by Na+-Ca2+ exchangers in mouse odontoblast lineage cells

    • Author(s)
      Sato M, Sobhan U, Tsumura M, Ichikawa H, Tazaki M, Muramatsu T, Shibukawa Y
    • Organizer
      6th International Conference on Na+/Ca2+ Exchange 2011
    • Place of Presentation
      Naples, Italy
    • Related Report
      2011 Research-status Report
  • [Presentation] 象牙芽細胞におけるTRPM8/TRPA1チャネルの発現の検索

    • Author(s)
      高橋史子、津村麻記、Sobhan Ubaidus、村松敬、佐藤正樹、市川秀樹、田崎雅和、澁川義幸
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜市
    • Related Report
      2011 Research-status Report
  • [Presentation] ユージノールは象牙芽細胞のTRPV1チャネルに作用する

    • Author(s)
      田中らいら、佐藤正樹、津村麻記、Sobhan Ubaidus、市川秀樹、田崎雅和、澁川義幸
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      岐阜市
    • Related Report
      2011 Research-status Report
  • [Presentation] Imunolocalization of potassium dependent (NCKX) and potassium independent (NCX) Na+/Ca2+ exchanger proteins in salivary glands

    • Author(s)
      Sobhan Ubaidus, Muramatsu Takashi, Tsumura Maki, Sato masaki, Tazaki Masakazu, Shibukawa Yoshiyuki
    • Organizer
      第89回日本生理学会
    • Place of Presentation
      松本市
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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