| Project/Area Number |
23792133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Hoshi University |
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Principal Investigator |
IKEDA Hiroko 星薬科大学, 薬学部, 講師 (70297844)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 歯科薬理学 / ジスキネジア / 大脳基底核 / ドパミン / 線条体 / 側坐核 / in vivo microdialysis |
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| Research Abstract |
Central dopamine (DA) systems are key players in the cerebral organization of behavior and various diseases. We show that stimulation of DA D_1/2 receptors in the accumbal shell decreased dorsal striatal DA efflux via a direct or indirect feed-forward loop involving shell, core, ventrolateral striatum (VLS) and dorsal striatum (DS): stimulation of D_1/2 receptors in the shell decreased DA efflux in the core; inhibition ofD_1/2 receptors in the core increased DA efflux in the VLS, and stimulation of D_1/2 receptors in the VLS decreased DA efflux in the DS. Finally, stimulation of D_1/2 receptors in the shell decreased DA efflux in the DS. Thus, we provide evidence in favor of the existence ofspiraling striato-nigro-striatal connections.
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