Regulatory mechanism of actin-ring formation through Wnt5a-Ror2 signaling pathway in osteoclasts
Project/Area Number |
23792134
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Matsumoto Dental University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 破骨細胞 / 骨吸収 / 極性化 / Wnt5a / Ror2 / Wnt5a / Ror2 / Rho / Wnt非古典経路 |
Research Abstract |
Reorganization of actin cytoskeleton and formation of actin rings in osteoclasts are necessary for bone-resorbing activity. Ror2, a receptor of Wnt5a, was expressed in osteoclasts. Ror2 deficient osteoclasts failed to form actin rings. Furthermore, we revealed that activation of Rho via Daam2 was required for actin ring formation downstream of Ror2.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Wnt5a-Ror2 signaling between osteoblasts and osteoclast precursors enhances osteoclastogenesis2012
Author(s)
Maeda, K., Kobayashi, Y., Udagawa, N., Uehara, S., Ishihara, A., Mizoguchi, T., Kikuchi, Y., Takada, I., Kato, S., Kani, S., Nishita, M., Marumo, K., Martin, T.J., Minami, Y., Takahashi, N.
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Journal Title
Nat.Med.
Volume: (印刷中)
Issue: 3
Pages: 405-12
DOI
Related Report
Peer Reviewed
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