Research Project
Grant-in-Aid for Young Scientists (B)
Reorganization of actin cytoskeleton and formation of actin rings in osteoclasts are necessary for bone-resorbing activity. Ror2, a receptor of Wnt5a, was expressed in osteoclasts. Ror2 deficient osteoclasts failed to form actin rings. Furthermore, we revealed that activation of Rho via Daam2 was required for actin ring formation downstream of Ror2.
All 2012 2011 Other
All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (11 results)
J Cell Biol
Volume: 197 Issue: 4 Pages: 553-568
10.1083/jcb.201111116
Nat.Med.
Volume: (印刷中) Issue: 3 Pages: 405-12
10.1038/nm.2653
Bone
Volume: 49 Issue: 6 Pages: 1331-1339
10.1016/j.bone.2011.09.045