Roles of a heretical Wnt receptor, Ryk for bone remodeling
Project/Area Number |
23792135
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Functional basic dentistry
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Research Institution | Matsumoto Dental University |
Principal Investigator |
NAKAMICHI Yuko 松本歯科大学, 総合歯科医学研究所, 講師 (20350829)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 骨代謝 / Wnt, Ryk, 骨芽細胞 / 破骨細胞 / 発生・分化 / 破骨細胞前駆細胞 / Ryk / Wnt |
Research Abstract |
The purpose of this study is clarifying a role of atypical Wnt receptor Ryk in the bone metabolism. Ryk was called a heretical Wnt receptor because of its function and properties in both canonical and non-canonical Wnt pathway. Ryk binds to Wnt3a (a canonical ligand) and Wnt5a (a non-canonical ligand), and transduces signals to control many biological processes. Ryk is expressed in both osteoclast-lineage cells and osteoblasts. Wegenerated conditional Ryk knockout mice to delete Ryk gene in these cells.
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Report
(3 results)
Research Products
(17 results)
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[Journal Article] Lineage-Committed Osteoclast Precursors Circulate in Blood and Settle Down Into Bone2011
Author(s)
Muto, A, Mizoguchi, T, Udagawa, N., Ito, S, Kawahara, I, Abiko, Y, Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y, Penninger, JM, Noguchi, T, Takahashi, N.
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Journal Title
Journal of Bone and Mineral Research
Volume: 26
Issue: 12
Pages: 2978-2990
DOI
Related Report
Peer Reviewed
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[Presentation] Spleen serves as a reservoir of osteoclast precursors through IL-34 expression in op/op mice2012
Author(s)
Nakamichi Y, Mizoguchi T, Arai A, Kobayashi Y, Penninger JM, Yasuda H, Kato S, DeLuca HF, Suda T, Udagawa N, Takahashi N
Organizer
4th InternationalConference on Osteoimmunology(第4回国際骨免疫学会議)
Place of Presentation
Chandris Hotel(コルフ島,ギリシア)
Year and Date
2012-06-21
Related Report
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