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Roles of a heretical Wnt receptor, Ryk for bone remodeling

Research Project

Project/Area Number 23792135
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Functional basic dentistry
Research InstitutionMatsumoto Dental University

Principal Investigator

NAKAMICHI Yuko  松本歯科大学, 総合歯科医学研究所, 講師 (20350829)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords骨代謝 / Wnt, Ryk, 骨芽細胞 / 破骨細胞 / 発生・分化 / 破骨細胞前駆細胞 / Ryk / Wnt
Research Abstract

The purpose of this study is clarifying a role of atypical Wnt receptor Ryk in the bone metabolism. Ryk was called a heretical Wnt receptor because of its function and properties in both canonical and non-canonical Wnt pathway. Ryk binds to Wnt3a (a canonical ligand) and Wnt5a (a non-canonical ligand), and transduces signals to control many biological processes. Ryk is expressed in both osteoclast-lineage cells and osteoblasts. Wegenerated conditional Ryk knockout mice to delete Ryk gene in these cells.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2012 2011 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results) Presentation (10 results) (of which Invited: 1 results)

  • [Journal Article] Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.2012

    • Author(s)
      Nakamichi Y et al.
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Issue: 25 Pages: 10006-10011

    • DOI

      10.1073/pnas.1207361109

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] c-Fos plays an essential role in the up-regulation of RANK expression in osteoclast precursors within the bone microenvironment2012

    • Author(s)
      Arai A, et al
    • Journal Title

      J Cell Sci

      Volume: (印刷中) Pages: 2910-2917

    • DOI

      10.1242/jcs.099986

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Daily administration of Eldecalcitol (ED-71), an active vitamin Danalog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone2012

    • Author(s)
      Harada S, et al
    • Journal Title

      J Bone Miner Res

      Volume: 27 Issue: 2 Pages: 461-473

    • DOI

      10.1002/jbmr.555

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-Committed Osteoclast Precursors Circulate in Blood and Settle Down Into Bone2011

    • Author(s)
      Muto, A, Mizoguchi, T, Udagawa, N., Ito, S, Kawahara, I, Abiko, Y, Arai, A., Harada, S., Kobayashi, Y., Nakamichi, Y, Penninger, JM, Noguchi, T, Takahashi, N.
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 26 Issue: 12 Pages: 2978-2990

    • DOI

      10.1002/jbmr.490

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 破骨細胞前駆細胞の形成と供 給におけるビタミン D の役割の新知見2011

    • Author(s)
      中道裕子
    • Journal Title

      THE BONE

      Volume: 25 Pages: 233-237

    • URL

      http://www.de-hon.ne.jp/digital/tmp/4A03DDAE2E9E40899044B70D623658FC/2000003264009800600P0B.pdf

    • Related Report
      2012 Final Research Report
  • [Journal Article] Rab27a and Rab27b are involved in stimulation-dependent RANKL release from secretory lysosomes in osteoblastic2011

    • Author(s)
      Kariya Y, et al
    • Journal Title

      J Bone Miner Res

      Volume: 26 Issue: 4 Pages: 689-703

    • DOI

      10.1002/jbmr.268

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hyergravity suppresses bone resorption in ovariectomized rat2011

    • Author(s)
      Ikawa T, et al
    • Journal Title

      Adv Space Res

      Volume: 47 Issue: 7 Pages: 1214-1224

    • DOI

      10.1016/j.asr.2010.12.004

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 破骨細胞形成におけるM-CSF/IL-34/RANKL のそれぞれの役割」2012

    • Author(s)
      中道裕子 ;
    • Organizer
      第15回骨発生・再生研究会
    • Place of Presentation
      慶応大学(東京都新宿区)
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] M-CSF 欠損 op/op マウスに おいて,脾臓は破骨細胞前駆細胞の貯蔵 庫として機能する:破骨細胞形成におけるIL-34 の新しい役割2012

    • Author(s)
      中道裕子 ,溝口利英,荒井敦,小林泰浩, 保田尚孝,加藤茂明,須田立雄,宇田川信 之,高橋直之
    • Organizer
      日本骨代謝学会学術 集会 (第30回)
    • Place of Presentation
      京王プ ラザホテル(東京都新宿区)
    • Year and Date
      2012-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Spleen serves as a reservoir of osteoclast precursors through IL-34 expression in op/op mice2012

    • Author(s)
      Nakamichi Y, Mizoguchi T, Arai A, Kobayashi Y, Penninger JM, Yasuda H, Kato S, DeLuca HF, Suda T, Udagawa N, Takahashi N
    • Organizer
      4th InternationalConference on Osteoimmunology(第4回国際骨免疫学会議)
    • Place of Presentation
      Chandris Hotel(コルフ島,ギリシア)
    • Year and Date
      2012-06-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 破骨細胞形成におけるM-CSF/RANKL/IL-34のそれぞれの役割2012

    • Author(s)
      中道裕子,荒井敦,小林泰浩,宇田川信之,高橋直之;
    • Organizer
      松本歯科大学学会例会(第75回)
    • Place of Presentation
      松本歯科大学(長野県塩尻市
    • Year and Date
      2012-01-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Dental Pulp Cells Exhibit High Performance as a Biomaterial for Bone Formation Through Expression of Annexin A82011

    • Author(s)
      Nakamichi Y, Hagihara T, Nakamura M, Imaoka A, Abiko Y, Nakamura H, Takahashi N, Udagawa N.
    • Organizer
      第31回米国骨代謝学会
    • Place of Presentation
      サンディエゴコンベンションセンター(カリフォルニア州,米国)
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯髄細胞の有する顕著な骨再生能力は、annexin A8を介して発揮される2011

    • Author(s)
      中道裕子,萩原貴寛,中村美どり,高橋直之,宇田川信之
    • Organizer
      日本骨代謝学会 (第29回)
    • Place of Presentation
      大阪国際会議場(大阪市北区)
    • Year and Date
      2011-07-30
    • Related Report
      2012 Final Research Report
  • [Presentation] 歯髄細胞の有する顕著な骨再生能力は、annexin A8を介して発揮される2011

    • Author(s)
      中道裕子,萩原貴寛,中村美どり,高橋直之,宇田川信之
    • Organizer
      日本骨代謝学会 (第29回)
    • Place of Presentation
      大阪国際会議場(大阪市)
    • Related Report
      2011 Research-status Report
  • [Presentation] Dental pulp cells exhibit high performance as a biomaterial for bone formation through expression of annexin A8.2011

    • Author(s)
      Nakamichi Y, Hagihara T, Nakamura M, Imaoka A, Abiko Y, Nakamura H, Takahashi N, Udagawa N
    • Organizer
      33th American Society for Bone and Mineral Research (ASBMR)
    • Place of Presentation
      サンディエゴコンベンションセンター (USA)
    • Related Report
      2011 Research-status Report
  • [Presentation] Spleen serves as a reservoir of osteoclast precursors through IL-34 expression in op/op mice: A pivotal role of IL-34 in osteoclastogenesis

    • Author(s)
      中道裕子
    • Organizer
      第4回国際骨免疫学会議
    • Place of Presentation
      ギリシア、コルフ島
    • Related Report
      2012 Annual Research Report
  • [Presentation] 破骨細胞形成におけるM-CSF/IL-34/RANKLのそれぞれの役割

    • Author(s)
      中道 裕子
    • Organizer
      第15回骨発生・再生研究会
    • Place of Presentation
      東京 (慶応大学)
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2011-08-05   Modified: 2019-07-29  

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