Study of inflammatory regulation by biotin via holocarboxylase synthetase
| Project/Area Number |
23792140
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 免疫 / 炎症 / 金属アレルギー / ビオチン / マクロファージ / 炎症制御 / ビタミン |
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| Research Abstract |
Biotin is a water-soluble B complex vitamin found in all organisms. To elucidate the mechanisms of inflammatory regulation by biotin, a holocarboxylase synthetase knock-down macrophage (HCS-KD cells) was constructed. The holocarboxylase synthetase (HCS) is a key-enzyme in cellular biotin metabolisms. The production of tumor necrosis factor-α, an important bioactive protein that involved with inflammation, was decreased in the HCS-KD cells. On the other hand, CD11b, an adhesive protein that involved with inflammation, was up-regulated in the HCS-KD cells.
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] Analgesic effects of the non-nitrogen- containing bisphosphonates etid- ronate and clodronate, independent of anti-resorptive effects on bone2013
Author(s)
Kim, Y., Seiryu, M., Okada, S., Kuroishi, T., Takano-Yamamoto, T., Sugawara, S., Endo, Y
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Journal Title
European Journal of Pharmacology
Volume: 699
Pages: 14-22
Related Report
Peer Reviewed
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[Journal Article] Histamine reduces susceptibility to natural killer cells via down- regulation of NKG2D ligands on human monocytic leukaemia THP-1 cells2012
Author(s)
Nagai, Y., Tanaka, Y., Kuroishi, T., Sato, R., Endo, Y., Sugawara, S
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Journal Title
Immunology
Volume: 136
Pages: 103-114
Related Report
Peer Reviewed
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[Journal Article] Biotinylation is a natural, albeit rare, modification of human histones2011
Author(s)
Kuroishi, T., Rios-Avila, L., Pestinger, V., Wijeratne, S.S.K., Zempleni, J
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Journal Title
Molecular Genetics and Metabolism
Volume: 104
Pages: 537-545
Related Report
Peer Reviewed
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