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A study of the suppression mechanism of tongue cancer growth/ metastasis by Sprouty, the regulating factor of MAP kinase cascade.

Research Project

Project/Area Number 23792146
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionKurume University (2013)
Kyushu University (2011-2012)

Principal Investigator

TAKETOMI Takaharu  久留米大学, 医学部, 助教 (10553290)

Project Period (FY) 2011 – 2013
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsSprouty / 舌癌 / 口腔癌 / MAPK 経路 / TGF-β シグナル
Research Abstract

After examining the expression of Sprouty/Spred family in the human tongue cancer cell line, expression of Sprouty2,4 and Spred1 was expressed and each expression was induced through MAPK cascade. Among them, Sprouty2 inhibited not only the activation of MAPK induced by EGF and FGF stimulation in tongue cancer cell line but also inhibited the activation of Smad 1/5/8 due to the transforming growth factor-beta superfamily stimulation to be known as yet another cancer growth signal.
Furthermore, Sprouty2 suppressed the expression of vascular epidermal growth factor (VEGF) in tongue cancer cell line, so it was suggested that Sprouty2 was associated with the suppression of the metastatic mechanism as well as the growth.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Research-status Report
  • 2011 Research-status Report
  • Research Products

    (16 results)

All 2014 2013 2012 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (12 results)

  • [Journal Article] Zoledronic Acid Enhances Lipopolysaccharide -Stimulated Proinflammatory Reactions through Controlled Expression of SOCS1 in Macrophages2013

    • Author(s)
      Daichi Muratsu, Daigo Yoshiga, Takaharu Taketomi, Tomohiro Onimura, Yoshihiro Seki, Akinobu Matsumoto, Seiji Nakamura
    • Journal Title

      PLOS ONE

      Volume: 8 (7) Issue: 7 Pages: e67906-e67906

    • DOI

      10.1371/journal.pone.0067906

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of Novel Amelogenin-Binding Proteins by   Proteomics Analysis2013

    • Author(s)
      Takao Fukuda, Terukazu Sanui, Kyosuke Toyoda, Urara Tanaka, Takaharu Taketomi, Takeshi Uchiumi, Fusanori Nishimura.
    • Journal Title

      PLOS ONE

      Volume: 8(10) Issue: 10 Pages: e78129-e78129

    • DOI

      10.1371/journal.pone.0078129

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 下顎骨骨切り術中の甲状腺クリーゼ発症により判明したバセドウ病の1例2013

    • Author(s)
      緒方絹子,武富孝治,高野雅代,津山治己,岩本修,楠川仁悟
    • Journal Title

      日本口腔外科学会誌

      Volume: Vol.59, No.12 Pages: 796-800

    • NAID

      40019931087

    • URL

      https://www.jstage.jst.go.jp/browse/jjoms/-char/ja/

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 下顎骨切り術中の甲状腺クリーゼ発症により判明した バセドウ病の 1 例2013

    • Author(s)
      緒方 絹子, 武富 孝治, 高野 雅代, 津山 治己, 岩本 修, 楠川仁悟
    • Journal Title

      日本口腔外科学会雑誌

      Volume: 59 Pages: 796-800

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] 軟口蓋に発生した基底細胞腺癌の1例2014

    • Author(s)
      武富孝治,中村守厳,原田真知子,古賀真,津山治己,岩本修,楠川仁悟
    • Organizer
      第32回日本口腔腫瘍学会総会
    • Place of Presentation
      札幌
    • Year and Date
      2014-01-23
    • Related Report
      2013 Final Research Report
  • [Presentation] 軟口蓋に発生した基底細胞腺癌の 1 例2014

    • Author(s)
      武富 孝治, 中村 守厳, 原田 真知子, 古賀 真, 津山 治己, 岩本 修, 楠川 仁悟
    • Organizer
      第32回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] 肉腫が疑われた上顎骨 MTX 関連顎骨壊死の 1 例2014

    • Author(s)
      津山 治己, 原田 真知子, 武富 孝治, 岩本 修, 楠川 仁悟
    • Organizer
      第32回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      札幌
    • Related Report
      2013 Annual Research Report
  • [Presentation] FGFアンタゴニストSprouty2による骨芽細胞増殖・分化制御機構の解明2013

    • Author(s)
      武富孝治,鬼村朋宏,吉賀大午,松村香織,中村誠司,吉村昭彦,楠川仁悟
    • Organizer
      第20回BMP研究会
    • Place of Presentation
      浜松
    • Year and Date
      2013-07-05
    • Related Report
      2013 Final Research Report
  • [Presentation] Sprouty2 regulates osteoblastogenesis via Runx2 signaling2013

    • Author(s)
      Sanui Terukazu, Tanaka Urara, Toyoda Kyosuke, Fukuda Takao, Takaharu Taketomi, Atomura Ryo, Hamachi Takafumi, Maeda Katsumasa
    • Organizer
      91nd General Session & Exhibition of the IADR
    • Place of Presentation
      Helsinki
    • Year and Date
      2013-03-23
    • Related Report
      2013 Final Research Report
  • [Presentation] FGFシグナル抑制因子Sprouty2による骨芽細胞増殖制御機構の解析2012

    • Author(s)
      鬼村朋宏,武富孝治,吉賀大午,村津大地,中村誠司
    • Organizer
      第30回骨代謝学会
    • Place of Presentation
      東京
    • Year and Date
      2012-07-20
    • Related Report
      2013 Final Research Report
  • [Presentation] FGFシグナル抑制因子Sproutyによる骨芽細胞増殖制御機構の解析2012

    • Author(s)
      鬼村朋宏,武富孝治,吉賀大午,村津大地,中村誠司
    • Organizer
      第66回日本口腔科学会学術集会
    • Year and Date
      2012-05-17
    • Related Report
      2013 Final Research Report
  • [Presentation] FGF アンタゴニスト Sprouty2 による 骨芽細胞増殖・分化制御機構の解明

    • Author(s)
      武富 孝治、鬼村 朋宏、吉賀 大午、松村 香織、 中村 誠司、吉村 昭彦、楠川 仁悟
    • Organizer
      第20回BMP研究会
    • Place of Presentation
      浜松
    • Related Report
      2013 Annual Research Report
  • [Presentation] Level V 領域へ転移をきたした 口腔扁平上皮癌症例の臨床病理学的検討

    • Author(s)
      武富 孝治, 中村 謙, 中村 守厳, 古賀 真, 岩本 修, 楠川 仁悟
    • Organizer
      第81回 口腔外科学会九州支部学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] FGF アンタゴニスト Sprouty2 による骨芽細胞増殖・分化制御機構の解明

    • Author(s)
      武富孝治、鬼村朋宏、吉賀大午、中村誠司、吉村昭彦、 楠川仁悟
    • Organizer
      第20回 BMP 研究会
    • Place of Presentation
      浜松
    • Related Report
      2012 Research-status Report
  • [Presentation] FGF シグナル抑制因子 Sprouty2 による骨芽細胞増殖制御機構の解析

    • Author(s)
      鬼村朋宏、武富孝治、吉賀大午、村津大地、中村誠司
    • Organizer
      第30回骨代謝学会
    • Place of Presentation
      東京
    • Related Report
      2012 Research-status Report
  • [Presentation] FGF シグナル抑制因子 Sprouty による骨芽細胞増殖制御機構の解析

    • Author(s)
      鬼村朋宏、武富孝治、吉賀大午、村津大地、中村誠司
    • Organizer
      第66回日本口腔科学会学術集会
    • Place of Presentation
      広島
    • Related Report
      2012 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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