| Project/Area Number |
23792150
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
KITO Shinji 九州歯科大学, 歯学部, 助教 (80347682)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | nucleolin / nucleophosmin / アポトーシス / 18F-FDG-PET-CT / 辺縁性歯周炎 / 根尖性歯周囲炎 / 生理的集積 / 舌 / 根尖性歯周炎 / 1人で単独で行う / 国内で単独で行う |
|---|
| Research Abstract |
Dynamic alteration of nucleolin and AgNORs proteins in UV-induced SCC-25 and HSG cells were examined using Western blot analysis and histocytochemistry methods. Dynamic alteration of nucleolin and AgNORs proteins are observed. With regard to nuclear medicine, A significant correlation was found between the size of bone resorption area by periapical or periodontal inflammation and standardized uptake value with the highest point (SUVmax) of 18F-FDG accumulations. 18F-FDG accumulations could exactly reflect the extent of the dental inflammation. 18F-FDG-PET-positive areas, excluding primary tumors, included the front intrinsic muscles of the tongue (89.0%), upper and lower marginal parts of the orbicularis oris muscle (64.6%), sublingual glands, palatine tonsil, pharyngeal tonsil, and lingual tonsil. In addition, some areas in the jaws also showed accumulation.
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